van Ede Annelies, den Broeder Alfons, Wagenaar Michiel, van Riel Piet, Creemers Marjonne C W
Department of Rheumatology, University Medical Centre Nijmegen, Nijmegen, The Netherlands.
J Rheumatol. 2007 Jul;34(7):1590-2. Epub 2007 Jun 15.
Although nodulosis is a common extraarticular manifestation of rheumatoid arthritis, accelerated pulmonary nodulosis is a rare event. The etiology of rheumatoid nodules is still unknown. Nodulosis is not necessarily associated with active joint inflammation, suggesting different pathogenic mechanisms for nodule formation and synovial tissue inflammation. We describe a patient with extensive pulmonary nodulosis, probably related to etanercept treatment. Our case emphasizes the need for careful monitoring for adverse events during treatment with biologicals, especially since the differential diagnosis often includes a broad spectrum of diseases.
尽管结节病是类风湿关节炎常见的关节外表现，但加速进展的肺结节病却很罕见。类风湿结节的病因仍不清楚。结节病不一定与活动性关节炎症相关，这表明结节形成和滑膜组织炎症的致病机制不同。我们描述了一名患有广泛肺结节病的患者，可能与依那西普治疗有关。我们的病例强调了在使用生物制剂治疗期间仔细监测不良事件的必要性，特别是因为鉴别诊断通常包括多种疾病。
