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膀胱过度活动症患者对缓释托特罗定或奥昔布宁的满意度

Patient satisfaction with extended release tolterodine or oxybutynin in overactive bladder.

作者信息

Bolge Susan C, McDonnell Diana D, Chen Andrew, Wan George J

机构信息

Consumer Health Sciences, Princeton, NJ 08540, USA.

出版信息

Curr Med Res Opin. 2007 Aug;23(8):1903-12. doi: 10.1185/030079907X210598.

Abstract

OBJECTIVE

To evaluate the effects of individual and condition characteristics on satisfaction with extended release tolterodine or oxybutynin in overactive bladder (OAB).

METHODS

Data were from the 2005 National Health and Wellness Survey, an annual, nationally representative, self-administered, internet-based survey of 40,000+ US adults (age 18+). Inclusion criteria for analysis were diagnosed OAB and using extended release tolterodine or oxybutynin but no other prescription medications for OAB. Satisfaction with extended release tolterodine or oxybutynin was rated on a five-point scale from 1 = not at all satisfied to 5 = extremely satisfied. Linear regression was used to evaluate independent effects demographics, patient perception of OAB, duration of use, requesting of medication, type of prescribing physician, medication compliance, and mental and physical health-related quality of life (Medical Outcomes Study, Eight-item Short-Form Health Survey; SF-8) on treatment satisfaction.

RESULTS

There were 345 patients who met the inclusion criteria. Apparent predictors of medication satisfaction, in order of magnitude of effect, were: feelings that OAB is just an inconvenience (standardized beta = -0.28; p < 0.001); less impact of OAB on daily life (standardized beta = 0.24; p < 0.001); longer duration of use (standardized beta = 0.10; p = 0.052); overwhelming urges to urinate (standardized beta = 0.10; p = 0.061); younger age (standardized beta = -0.10; p = 0.054); and more frequent medication use (standardized beta = 0.09; p = 0.096).

LIMITATIONS

Data were cross-sectional and self-reported by patients via the internet.

CONCLUSIONS

Patient treatment satisfaction is affected by perceptions of OAB symptoms and impact, as well as consistent, long-term use of prescription treatments. Clinicians should reinforce to patients the importance of long-term compliance for successful treatment.

摘要

目的

评估个体及病情特征对膀胱过度活动症(OAB)患者使用托特罗定缓释剂或奥昔布宁的满意度的影响。

方法

数据来自2005年全国健康与 Wellness 调查,这是一项针对40,000多名美国成年人(18岁及以上)的年度全国代表性自我管理网络调查。分析的纳入标准为诊断为OAB且正在使用托特罗定缓释剂或奥昔布宁,但未使用其他治疗OAB的处方药。对托特罗定缓释剂或奥昔布宁的满意度采用五点量表进行评分,从1分(完全不满意)到5分(极其满意)。使用线性回归来评估人口统计学、患者对OAB的认知、使用时长、药物需求、开处方医生类型、药物依从性以及与身心健康相关的生活质量(医学结果研究,八项简短健康调查;SF-8)对治疗满意度的独立影响。

结果

有345名患者符合纳入标准。按影响程度排序,药物满意度的明显预测因素为:认为OAB只是带来不便(标准化β=-0.28;p<0.001);OAB对日常生活影响较小(标准化β=0.24;p<0.001);使用时间较长(标准化β=0.10;p=0.052);强烈的排尿冲动(标准化β=0.10;p=0.061);年龄较小(标准化β=-0.10;p=0.054);以及更频繁使用药物(标准化β=0.09;p=0.096)。

局限性

数据为横断面数据,由患者通过互联网自我报告。

结论

患者的治疗满意度受对OAB症状及其影响的认知以及持续长期使用处方治疗的影响。临床医生应向患者强调长期依从性对成功治疗的重要性。

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