突触兴奋-分泌偶联中膜融合的调控：速度与准确性至关重要。
Regulation of membrane fusion in synaptic excitation-secretion coupling: speed and accuracy matter.
作者信息
Wojcik Sonja M, Brose Nils
机构信息
Max-Planck-Institut für Experimentelle Medizin, Abteilung Molekulare Neurobiologie, Hermann-Rein-Strasse 3, D-37075 Göttingen, Deutschland.
出版信息
Neuron. 2007 Jul 5;55(1):11-24. doi: 10.1016/j.neuron.2007.06.013.
Unlike most other secretory processes, neurotransmitter release at chemical synapses is extremely fast, tightly regulated, spatially restricted, and dynamically adjustable at the same time. In this review, we focus on recent discoveries of molecular and cell biological processes that determine how fusion competence of vesicles is achieved and controlled in order to suit the specific requirements of synaptic transmitter release with respect to speed and spatial selectivity.
与大多数其他分泌过程不同，化学突触处的神经递质释放极其迅速，受到严格调控，在空间上受到限制，并且同时具有动态可调性。在本综述中，我们重点关注分子和细胞生物学过程的最新发现，这些过程决定了囊泡的融合能力是如何实现和控制的，以便满足突触递质释放对速度和空间选择性的特定要求。
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