Verhage Matthijs, Toonen Ruud Fg
Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam (VUA) and VU University Medical Center (VUmc), De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands.
Curr Opin Cell Biol. 2007 Aug;19(4):402-8. doi: 10.1016/j.ceb.2007.05.002. Epub 2007 Jul 16.
Cellular trafficking pathways end with fusion reactions at the target. These reactions have been studied extensively for many decades, but recent studies have been particularly productive in providing new solutions to old problems, especially in some of the most complex fusion reactions, like synaptic vesicle secretion in neurons. Here, we discuss new studies that begin to merge ideas on three central questions: (A) are all releasable vesicles equally likely to undergo fusion, (B) do different fusion modes contribute to synaptic transmission, and (C) which molecular events are 'upstream' and which ones 'downstream' of SNARE complex assembly.
细胞运输途径在靶标处通过融合反应结束。数十年来，这些反应已得到广泛研究，但最近的研究在为老问题提供新解决方案方面尤其富有成效，特别是在一些最复杂的融合反应中，比如神经元中的突触小泡分泌。在这里，我们讨论一些新研究，这些研究开始融合关于三个核心问题的观点：（A）所有可释放的小泡发生融合的可能性是否相同，（B）不同的融合模式是否对突触传递有贡献，以及（C）哪些分子事件处于SNARE复合体组装的“上游”，哪些处于“下游”。
