Tsukioka Miho, Matsumoto Yoshinari, Noriyuki Maiko, Yoshida Chika, Nobeyama Hiroyuki, Yoshida Hiroyuki, Yasui Tomoyo, Sumi Toshiyuki, Honda Ken-Ichi, Ishiko Osamu
Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
Oncol Rep. 2007 Aug;18(2):361-7.
We immunohistochemically examined the expression of the glucose transporters (GLUT)1, GLUT3 and GLUT4, in 154 tumor samples of epithelial ovarian carcinoma. In addition, we investigated the correlations between the expression of GLUTs and the vascular endothelial growth factor (VEGF), and microvessel count and clinical parameters. The rates of expression of GLUT1, GLUT3 and GLUT4 were 98.7%, 92.8% and 84.4%, respectively. GLUT1 and GLUT4 were both strongly expressed in serous adenocarcinoma, but weakly expressed in clear cell adenocarcinoma. The expressions of GLUT1 and GLUT4 correlated with the clinical disease stage. The expressions of GLUT1, GLUT3 and GLUT4 correlated positively with VEGF expression. The expression status for GLUT1, GLUT3, GLUT4 and VEGF did not represent a prognostic factor. These findings suggest that characteristic differences in the patterns of glucose uptake can exist according to the histological type and that GLUT1, GLUT3 and GLUT4 could be related to tumor angiogenesis in epithelial ovarian carcinoma.
我们采用免疫组化方法检测了154例上皮性卵巢癌肿瘤样本中葡萄糖转运蛋白（GLUT）1、GLUT3和GLUT4的表达情况。此外，我们还研究了葡萄糖转运蛋白表达与血管内皮生长因子（VEGF）、微血管计数及临床参数之间的相关性。GLUT1、GLUT3和GLUT4的表达率分别为98.7%、92.8%和84.4%。GLUT1和GLUT4在浆液性腺癌中均呈强表达，而在透明细胞腺癌中呈弱表达。GLUT1和GLUT4的表达与临床疾病分期相关。GLUT1、GLUT3和GLUT4的表达与VEGF表达呈正相关。GLUT1、GLUT3、GLUT4和VEGF的表达状态并非预后因素。这些发现表明，根据组织学类型，葡萄糖摄取模式可能存在特征性差异，且GLUT1、GLUT3和GLUT4可能与上皮性卵巢癌的肿瘤血管生成有关。
