Ben Ali Fatima, Qmichou Zineb, Oukabli Mohamed, Dakka Nadia, Bakri Youssef, Eddouks Mohammed, Ameziane El Hassani Rabii
Laboratory of Biology of Human Pathologies (BioPatH), Faculty of Sciences, Mohammed V University in Rabat, Rabat 10001, Morocco.
Medical Biotechnology Center, Moroccan Foundation for Advanced Science, Innovation and Research (MAScIR), Rabat 10001, Morocco.
Explor Target Antitumor Ther. 2024;5(2):384-399. doi: 10.37349/etat.2024.00224. Epub 2024 Apr 24.
Aerobic glycolysis also known as the Warburg effect, remains a hallmark of various cancers, including ovarian cancer. Cancer cells undergo metabolic changes to sustain their tumorigenic properties and adapt to environmental conditions, such as hypoxia and nutrient starvation. Altered metabolic pathways not only facilitate ovarian cancer cells' survival and proliferation but also endow them to metastasize, develop resistance to chemotherapy, maintain cancer stem cell phenotype, and escape anti-tumor immune responses. Glucose transporters (GLUTs), which play a pivotal role as the rate-limiting step in glycolysis, are frequently overexpressed in a variety of tumors, including ovarian cancer. Multiple oncoproteins can regulate GLUT proteins, promoting tumor proliferation, migration, and metastasis, either dependent or independent of glycolysis. This review examines the alteration of GLUT proteins, particularly GLUT1, in ovarian cancer and its impact on cancer initiation, progression, and resistance to treatment. Additionally, it highlights the role of these proteins as biomarkers for diagnosis and prognosis in ovarian cancer, and delves into novel therapeutic strategies currently under development that target GLUT isoforms.
有氧糖酵解也被称为瓦伯格效应，仍是包括卵巢癌在内的多种癌症的一个标志。癌细胞会发生代谢变化以维持其致瘤特性，并适应诸如缺氧和营养饥饿等环境条件。代谢途径的改变不仅有助于卵巢癌细胞的存活和增殖，还使其能够转移、产生化疗耐药性、维持癌症干细胞表型并逃避抗肿瘤免疫反应。葡萄糖转运蛋白（GLUTs）作为糖酵解中的限速步骤发挥着关键作用，在包括卵巢癌在内的多种肿瘤中经常过度表达。多种癌蛋白可以调节GLUT蛋白，促进肿瘤增殖、迁移和转移，无论是否依赖糖酵解。本综述探讨了卵巢癌中GLUT蛋白，特别是GLUT1的改变及其对癌症发生、进展和治疗耐药性的影响。此外，还强调了这些蛋白作为卵巢癌诊断和预后生物标志物的作用，并深入探讨了目前正在开发的针对GLUT异构体的新型治疗策略。
