中枢给予苯环利定对麻醉犬呼吸和循环系统的影响。

Respiratory and circulatory effects of centrally administered phencyclidine in anesthetized dogs.

Waters I W, Hackett R B, Obrosky K W, Davis W M

Department of Pharmacology, School of Pharmacy, University of Mississippi, University 38677.

Gen Pharmacol. 1991;22(5):975-83. doi: 10.1016/0306-3623(91)90241-w.

Abstract

Anesthetized dogs were given phencyclidine HCl (PCP) by intracerebroventricular (i.c.v.) injection. 2. Physiological parameters were monitored after consecutive doses of 0.5, 1.0 and 2.0 mg of PCP. 3. Dose-related changes seen, including bradycardia, hypotension and bradypnea, were opposite to those produced by i.v. doses. 4. Single doses of 1.0 or 2.0 mg of PCP confirmed the prior observations, and the latter provided the baseline for further observations on dogs receiving PCP before various i.c.v. pretreatments--atropine, haloperidol, phentolamine or propranolol--in efforts to characterize the central neurotransmitter system(s) involved in the PCP effects.

摘要

对麻醉犬进行脑室内注射盐酸苯环利定（PCP）。2. 连续给予0.5、1.0和2.0毫克PCP后监测生理参数。3. 观察到的剂量相关变化，包括心动过缓、低血压和呼吸减慢，与静脉注射剂量产生的变化相反。4. 单次给予1.0或2.0毫克PCP证实了先前的观察结果，后者为在各种脑室内预处理（阿托品、氟哌啶醇、酚妥拉明或普萘洛尔）之前接受PCP的犬的进一步观察提供了基线，以试图确定参与PCP效应的中枢神经递质系统。