Wagner G C, Masters D B, Tomie A
Psychopharmacology (Berl). 1984;84(1):32-8. doi: 10.1007/BF00432020.
Phencyclidine (PCP), haloperidol, and naloxone were administered alone and in combination to rats responding under a fixed-interval schedule for water presentation. Lower doses of PCP (0.25-2.0 mg/kg) and naloxone (0.001-0.1 mg/kg) produced increases while higher doses produced dose-dependent decreases in response rate. Haloperidol (0.0625-0.5 mg/kg) produced a monotonic dose-dependent decrease in responding. When a dose of naloxone (8.0 mg/kg) that did not alter responding was administered prior to the PCP, the PCP dose-response curve was shifted to 6.5-fold lower doses of PCP. When a dose of haloperidol (0.0625 mg/kg) that did not alter responding was administered prior to the PCP, the PCP dose-response curve was shifted to 1.5-fold higher dose of PCP. These observations are discussed in relation to current views of the mechanism of PCP action.
将苯环己哌啶（PCP）、氟哌啶醇和纳洛酮单独及联合给予按固定间隔程序接受水刺激的大鼠。较低剂量的PCP（0.25 - 2.0毫克/千克）和纳洛酮（0.001 - 0.1毫克/千克）会使反应率增加，而较高剂量则会使反应率呈剂量依赖性降低。氟哌啶醇（0.0625 - 0.5毫克/千克）会使反应呈单调的剂量依赖性降低。当在给予PCP之前先给予不改变反应的纳洛酮剂量（8.0毫克/千克）时，PCP剂量 - 反应曲线会向低6.5倍剂量的PCP方向移动。当在给予PCP之前先给予不改变反应的氟哌啶醇剂量（0.0625毫克/千克）时，PCP剂量 - 反应曲线会向高1.5倍剂量的PCP方向移动。结合当前对PCP作用机制的观点对这些观察结果进行了讨论。
