Ring Malvin E
J Calif Dent Assoc. 2007 Apr;35(4):275-82.
For hundreds of years, mankind has struggled with the problem of controlling pain during surgical procedures without putting the patient to sleep. In 1884, cocaine was discovered to have local anesthetic properties and soon became widely used in many types of surgery. The many undesirable properties of cocaine led scientists to find a safer alternative. Since then, more effective local anesthetics have been and continue to be developed.
数百年来,人类一直在努力解决在不使患者入睡的情况下控制外科手术疼痛的问题。1884年,可卡因被发现具有局部麻醉特性,并很快在许多类型的手术中广泛使用。可卡因的许多不良特性促使科学家寻找更安全的替代品。从那时起,更有效的局部麻醉剂不断被研发出来并持续发展。