小鼠结肠微循环的显微视频内镜检查。
Murine microvideo endoscopy of the colonic microcirculation.
作者信息
Ravnic Dino J, Konerding Moritz A, Huss Harold T, Wolloscheck Tanja, Pratt Juan P, Mentzer Steven J
机构信息
Department of Surgery, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.
出版信息
J Surg Res. 2007 Sep;142(1):97-103. doi: 10.1016/j.jss.2006.12.005. Epub 2007 Jul 5.
Abstract
Natural orifice endoscopy in small animal models has been limited in the past by instrument size and optical performance. In this report, we investigate the feasibility of using a recently developed microvideo endoscopy system to evaluate the colon microcirculation. Using a murine model of acute colitis, microvideo endoscopy was useful in mapping the topography of inflammation as well as identifying relevant structures in the microcirculation. We conclude that natural orifice endoscopy is a useful method for the minimally invasive longitudinal assessment of the colonic mucosal microcirculation.
摘要
在过去，小动物模型中的自然腔道内镜检查受到器械尺寸和光学性能的限制。在本报告中，我们研究了使用最近开发的微型视频内镜系统评估结肠微循环的可行性。利用急性结肠炎小鼠模型，微型视频内镜有助于描绘炎症的地形图以及识别微循环中的相关结构。我们得出结论，自然腔道内镜检查是对结肠黏膜微循环进行微创纵向评估的一种有用方法。
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