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阿片类药物的非法使用:奥施康定是“入门药物”吗?

Illicit use of opioids: is OxyContin a "gateway drug"?

作者信息

Grau Lauretta E, Dasgupta Nabarun, Harvey Alison Phinney, Irwin Kevin, Givens Anthony, Kinzly Mark L, Heimer Robert

机构信息

Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520-8034, USA.

出版信息

Am J Addict. 2007 May-Jun;16(3):166-73. doi: 10.1080/10550490701375293.

Abstract

This study examines whether individuals who engage in illicit, non-medical use of OxyContin are distinguishable from other non-medical users of opioids and whether OxyContin serves as a "gateway" to heroin and/or injection drug use. The study sample included active nonmedical users of opioids, who are 16 years or older and residents of Cumberland County, Maine. Possible associations between type of opioid used and behavioral and descriptive variables were assessed. The study sample was predominantly urban-dwelling, male, Caucasian, and economically disadvantaged. OxyContin users could only be distinguished from heroin users (cf non-heroin opioid users). Polyopioid use within the first year of initiation was associated with quicker progression to heroin and injection drug use.

摘要

本研究探讨了非法非医疗使用奥施康定的个体是否与其他非医疗使用阿片类药物的使用者有所不同,以及奥施康定是否充当了通往海洛因和/或注射吸毒的“门户”。研究样本包括年龄在16岁及以上、居住在缅因州坎伯兰县的现役非医疗阿片类药物使用者。评估了所使用阿片类药物类型与行为及描述性变量之间可能存在的关联。研究样本主要为居住在城市、男性、白种人且经济处于劣势的人群。奥施康定使用者仅能与海洛因使用者区分开来(对比非海洛因阿片类药物使用者)。开始使用后的第一年内使用多种阿片类药物与更快发展为使用海洛因和注射吸毒有关。

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