Krause U, Nink M, Brauer A, Huber I, Velten A, Lehnert H, Beyer J
III. Medizinische Klinik und Poliklinik-Endokrinologie, Universitätsklinik Mainz, Germany.
Horm Metab Res. 1991 Oct;23(10):499-503. doi: 10.1055/s-2007-1003738.
Following an intravenous injection of 100 micrograms hCRH a facial flushing can frequently be observed along with respiratory stimulation. Both effects can be mediated by a common transmitter. Serotonin is well known to produce facial flush as well as to modulate respiration. In order to clarify is serotonin is a common mediator for facial flush and respiratory stimulation after i.v. application of hCRH, we studied the time course of facial skin temperatures and respiratory stimulation after intravenous injection of 100 micrograms hCRH in 10 healthy subjects. Furthermore, we measured respiratory stimulation after i.v. administration of 100 micrograms hCRH in 10 healthy subjects pretreated with the serotonin antagonist cyproheptadine. Facial skin temperatures reached maximum levels 9 min after CRH administration and remained raised for more than 60 min. Respiratory stimulation occurred within the first minute after CRH administration and reached a maximum during the second minute, but could no longer be observed after 10 min. Serum serotonin levels did not change after CRH stimulation in doses up to 3 micrograms/kg body weight), and cyproheptadine did not abolish the respiratory stimulation effect of hCRH in a dosage sufficient to suppress CRH.-induced cortisol secretion.
静脉注射100微克人促肾上腺皮质激素释放激素（hCRH）后，常可观察到面部潮红以及呼吸刺激。这两种效应可能由一种共同的递质介导。众所周知，血清素可引起面部潮红并调节呼吸。为了明确血清素是否是静脉注射hCRH后面部潮红和呼吸刺激的共同介质，我们研究了10名健康受试者静脉注射100微克hCRH后面部皮肤温度和呼吸刺激的时间进程。此外，我们测量了10名预先用血清素拮抗剂赛庚啶治疗的健康受试者静脉注射100微克hCRH后的呼吸刺激情况。给予CRH后9分钟面部皮肤温度达到最高水平，并持续升高超过60分钟。呼吸刺激在给予CRH后的第一分钟内出现，并在第二分钟达到最大值，但10分钟后不再观察到。高达3微克/千克体重剂量的CRH刺激后血清素水平未发生变化，并且赛庚啶在足以抑制CRH诱导的皮质醇分泌的剂量下并未消除hCRH的呼吸刺激作用。
