Zaidi Asim R, Zaidi Ali, Vaitkus Paul T
Department of Medicine, St. George's Hospital, London, UK.
J Heart Lung Transplant. 2007 Jul;26(7):714-7. doi: 10.1016/j.healun.2007.05.006.
Cardiac transplantation has been utilized increasingly in patients with sarcoid cardiomyopathy. We sought to review outcomes in patients with sarcoidosis who had heart transplants and compared their outcomes with those of transplanted patients without sarcoidosis.
We retrospectively reviewed the United Network for Organ Sharing (UNOS) database to assess the survival of patients with sarcoidosis who were treated by heart transplantation.
Over an 18-year period, 65 patients (40 men and 25 women) with sarcoidosis underwent orthotopic heart transplantation. There were 4 operative deaths and 12 late deaths at a mean follow-up of 40 months. One-year post-transplant survival was significantly better for sarcoid patients receiving orthotopic transplantation compared with contemporaneous patients receiving transplantation for all other diagnoses (87.7% vs 84.5%, p = 0.030).
Patients with sarcoidosis undergoing orthotopic heart transplant had better short- and intermediate-term survival than the majority of heart transplant recipients. The diagnosis of sarcoidosis should not disqualify potential transplant candidates.
心脏移植在结节病性心肌病患者中的应用越来越多。我们试图回顾接受心脏移植的结节病患者的预后情况，并将他们的预后与非结节病性移植患者的预后进行比较。
我们回顾性分析了器官共享联合网络（UNOS）数据库，以评估接受心脏移植治疗的结节病患者的生存率。
在18年期间，65例（40例男性和25例女性）结节病患者接受了原位心脏移植。平均随访40个月，有4例手术死亡和12例晚期死亡。与同期接受其他所有诊断移植的患者相比，接受原位移植的结节病患者移植后1年生存率显著更高（87.7%对84.5%，p = 0.030）。
接受原位心脏移植的结节病患者比大多数心脏移植受者有更好的短期和中期生存率。结节病的诊断不应排除潜在的移植候选人。
