Gómez-Choco M J, Iranzo A, Blanco Y, Graus F, Santamaria J, Saiz A
Service of Neurology, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain.
Mult Scler. 2007 Jul;13(6):805-8. doi: 10.1177/1352458506074644. Epub 2007 Mar 15.
A total of 135 consecutive, unrelated, multiple sclerosis (MS) patients were interviewed for symptoms suggestive of restless legs syndrome (RLS) and REM sleep behavior disorder (RBD), using semi-structured questionnaires. Some 118 unrelated healthy controls of similar sex and age distribution were included for comparison. Patients and controls with equivocal symptoms were re-evaluated by a sleep disorders specialist and video-polisomnography in those who fulfilled the criteria for RBD. We did not find significant differences in frequency (13.3 versus 9.3%), proportion of females (66.7 versus 58.5%), and mean age (42.1+/-12.6 versus 43+/-7.8 years) among MS patients and controls with RLS. RBD was found in three patients (1.4%), one associated with antidepressant intake, but in none of the controls. Our study shows that RLS in MS is not more frequent than in the general population, and that RBD, although uncommon, may occur in the setting of this neurological disease.
我们使用半结构化问卷，对135例连续的、无亲缘关系的多发性硬化症（MS）患者进行了访谈，以了解是否存在不宁腿综合征（RLS）和快速眼动睡眠行为障碍（RBD）的提示性症状。纳入了约118例性别和年龄分布相似的无亲缘关系健康对照进行比较。症状不明确的患者和对照由睡眠障碍专家进行重新评估，对符合RBD标准的患者进行视频多导睡眠图检查。我们发现，MS患者和患有RLS的对照在频率（13.3%对9.3%）、女性比例（66.7%对58.5%）和平均年龄（42.1±12.6岁对43±7.8岁）方面没有显著差异。在3例患者（1.4%）中发现了RBD，其中1例与抗抑郁药摄入有关，但对照中均未发现。我们的研究表明，MS患者中RLS的发生率并不高于普通人群，并且RBD虽然不常见，但可能在这种神经系统疾病中出现。
