Douay X, Waucquier N, Hautecoeur P, Vermersch P
Cabinet de Neurologie, Lambersart, France.
Rev Neurol (Paris). 2009 Feb;165(2):194-6. doi: 10.1016/j.neurol.2008.06.001. Epub 2008 Jul 16.
Prevalence of restless legs syndrome (RLS), a clinically defined disorder, varies from 2.5 to 15% among populations. In the French adult population, prevalence is estimated to be 8.5%. RLS is often secondary to a variety of disorders. Neurological conditions usually associated with RLS are neuropathies and Parkinson's disease. There are few studies of its association with multiple sclerosis (MS). The aim of this study was to estimate RLS prevalence in a population of French MS patients. During one month, 17 neurologists from the G-SEP group prospectively recruited 242 patients who fulfilled the Mc Donald criteria for MS. Each patient underwent a standardised questionnaire to verify the international criteria of RLS. We collected date of birth, gender, MS course (relapsing remitting, primary progressive and secondary progressive) and MS duration. Forty-one subjects (18%) met the criteria for RLS. Comparing the RLS group with the group without RLS, no significant differences were found in age, gender and MS duration. RLS was more prevalent in the relapsing remitting MS group. Prevalence of RLS seems to be doubled in MS patients compared to the general population. This finding warrants further study. Identification of this syndrome in MS patients might lead to specific treatments.
不宁腿综合征（RLS）是一种临床定义的疾病，在不同人群中的患病率从2.5%到15%不等。在法国成年人群中，患病率估计为8.5%。RLS通常继发于多种疾病。通常与RLS相关的神经系统疾病是神经病变和帕金森病。关于其与多发性硬化症（MS）关联的研究较少。本研究的目的是估计法国MS患者群体中RLS的患病率。在一个月的时间里，G - SEP组的17名神经科医生前瞻性地招募了242名符合MS麦克唐纳标准的患者。每位患者都接受了一份标准化问卷，以核实RLS的国际标准。我们收集了出生日期、性别、MS病程（复发缓解型、原发进展型和继发进展型）以及MS病程时长。41名受试者（18%）符合RLS标准。将RLS组与无RLS组进行比较，在年龄、性别和MS病程时长方面未发现显著差异。RLS在复发缓解型MS组中更为普遍。与普通人群相比，MS患者中RLS的患病率似乎翻倍。这一发现值得进一步研究。在MS患者中识别出这种综合征可能会带来针对性的治疗方法。
