一种从澳洲绶草（R. Brown）Lindl. 的根中提取的新型抗癌二氢黄酮类化合物。

A new anticancer dihydroflavanoid from the root of Spiranthes australis (R. Brown) Lindl.

作者信息

Peng Jinyong, Xu Qiwei, Xu Youwei, Qi Yan, Han Xu, Xu Lina

机构信息

School of Pharmacy, Dalian Medical University, Dalian 116027, China.

出版信息

Nat Prod Res. 2007 Jun;21(7):641-5. doi: 10.1080/14786410701371165.

DOI:10.1080/14786410701371165

PMID:17613822

Abstract

A new dihydroflavanoid was obtained from the root of Spiranthes australis (R. Brown) Lindl, a traditional Chinese medicinal herb. The structure was elucidated as (2S)-5,2',6'-trihydroxy-6-lavandulyl-4''-(gamma,gamma-dimethylallyl)-2'',2''-dimethylpyrano-[5'',6'' : 7,8]-flavanone by spectroscopic methods including UV, IR, HR-EI-MS, ESI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activities of the compound to inhibit human cancer cells' growth including A549, BEL-7402, SGC-7901, MCF-7, HT-29, K562, and A498 cell lines by MTT method was evaluated in vitro.

摘要

从传统中草药澳洲绶草（Spiranthes australis (R. Brown) Lindl）的根部获得了一种新的二氢黄酮类化合物。通过紫外光谱（UV）、红外光谱（IR）、高分辨电子轰击质谱（HR-EI-MS）、电喷雾电离质谱（ESI-MS）、一维核磁共振（1D NMR）和二维核磁共振（2D NMR）等光谱方法确定其结构为(2S)-5,2',6'-三羟基-6-薰衣草基-4''-(γ,γ-二甲基烯丙基)-2'',2''-二甲基吡喃并-[5'',6'' : 7,8]-黄烷酮，随后，采用MTT法在体外评估了该化合物对人癌细胞系A549、BEL-7402、SGC-7901、MCF-7、HT-29、K562和A498生长的抑制抗癌活性。