一种来自柬埔寨龙血树的新型细胞毒性高异黄酮。

A new cytotoxic homoisoflavonoid from Dracaena cambodiana.

作者信息

Liu Jian, Mei Wen-Li, Wu Jiao, Zhao You-Xing, Peng Ming, Dai Hao-Fu

机构信息

Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.

出版信息

J Asian Nat Prod Res. 2009;11(2):192-5. doi: 10.1080/10286020802674962.

DOI:10.1080/10286020802674962

PMID:19219735

Abstract

A new homoisoflavonoid, named cambodianol (1), together with the two known flavanes, (2S)-7,3'-dihydroxy-4'-methoxy-8-methylflavane (2) and (2R)-7,4'-dihydroxy-8-methylflavane (3), were isolated from the stems of Dracaena cambodiana. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 1 exhibited significant cytotoxic activities against K562 and SGC-7901 with the IC(50) values of 1.4 and 2.9 microg/ml, respectively.

摘要

从柬埔寨龙血树的茎中分离出一种新的高异黄酮，命名为柬埔寨醇（1），以及两种已知的黄烷，（2S）-7,3'-二羟基-4'-甲氧基-8-甲基黄烷（2）和（2R）-7,4'-二羟基-8-甲基黄烷（3）。它们的结构通过高分辨电喷雾电离质谱（HR-ESI-MS）和光谱技术（紫外、红外、一维和二维核磁共振）确定。化合物1对K562和SGC-7901表现出显著的细胞毒活性，IC50值分别为1.4和2.9微克/毫升。