Vostrikov Vitaly V, Selishcheva Alla A, Sorokoumova Galina M, Shakina Yulia N, Shvets Vitaly I, Savel'ev Oleg Yu, Polshakov Vladimir I
M.V. Lomonosov State Academy of Fine Chemical Technology, Moscow, Russia.
Eur J Pharm Biopharm. 2008 Feb;68(2):400-5. doi: 10.1016/j.ejpb.2007.05.014. Epub 2007 Jun 3.
Distribution coefficient (D) of rifabutin in liposome/water system was measured by phase separation and fluorescence probe quenching techniques. D values were identical suggesting that rifabutin is fully immersed into lipid bilayer. Structural studies of phospholipid bilayer employing (31)P NMR spectroscopy demonstrated that introduction of rifabutin does not alter the bilayer structure. A scheme of the rifabutin position in lipid bilayer based on the calculated size of rifabutin molecule is proposed.
采用相分离和荧光探针猝灭技术测定了利福布汀在脂质体/水体系中的分配系数（D）。D值相同，表明利福布汀完全嵌入脂质双层中。利用（31）P核磁共振光谱对磷脂双层进行的结构研究表明，利福布汀的引入不会改变双层结构。基于利福布汀分子计算尺寸，提出了利福布汀在脂质双层中位置的示意图。
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