Dong Suzhen, Li Chunxia, Wu Pu, Tsien Joe Z, Hu Yinghe
Key Laboratory of Brain Functional Genomics, MOE&STCSM, Shanghai Institute of Brain Functional Genomics, East China Normal University, Shanghai, China 200062.
Eur J Neurosci. 2007 Jul;26(1):101-12. doi: 10.1111/j.1460-9568.2007.05641.x.
Presenilin (PS) 1 and 2 conditional double knockout (cDKO) mice show progressive memory dysfunction and forebrain degeneration. Gene expression profiling results revealed a strong activation of immunity and inflammation responses in the brains of 10-month-old cDKO mice. As environmental enrichment (EE) has been shown to be able to improve memory and induce neurogenesis of the brain, we assessed the effects of EE on the memory performance and the neurodegeneration in cDKO mice. We found that EE effectively enhanced memory and partially rescued the forebrain atrophy of the cDKO mice. Our results suggest that immunity and inflammation could play important roles in the neurodegeneration of cDKO mice. Furthermore, the beneficial effects of EE may be associated with the inhibition of the expression of immunity and inflammation-related genes in the brain.
早老素（PS）1和2条件性双敲除（cDKO）小鼠表现出进行性记忆功能障碍和前脑退化。基因表达谱分析结果显示，10月龄cDKO小鼠大脑中的免疫和炎症反应强烈激活。由于环境富集（EE）已被证明能够改善记忆并诱导大脑神经发生，我们评估了EE对cDKO小鼠记忆表现和神经退行性变的影响。我们发现，EE有效地增强了记忆，并部分挽救了cDKO小鼠的前脑萎缩。我们的结果表明，免疫和炎症可能在cDKO小鼠的神经退行性变中起重要作用。此外，EE的有益作用可能与抑制大脑中免疫和炎症相关基因的表达有关。
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