Lambiase Antonietta, Raia Valeria, Stefani Stefania, Sepe Angela, Ferri Pasqualina, Buonpensiero Paolo, Rossano Fabio, Del Pezzo Mariassunta
Department of Biology and Pathology, Luigi Califano, University of Naples Federico II, Italy.
J Microbiol. 2007 Jun;45(3):275-9.
The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01).
本研究的目的是在一组囊性纤维化患者（n = 276）中检测洋葱伯克霍尔德菌复合体（Bcc）菌株，并通过分子技术对Bcc分离株进行特征分析。结果显示，11.23%的患者感染了Bcc。第三代头孢菌素类洋葱伯克霍尔德菌III-A型是最常见的菌种（64.3%），其中，10%为cblA阳性，50%为esmR阳性。不到一半的菌株对头孢他啶、美罗培南、哌拉西林他唑巴坦和复方新诺明敏感。约一半的菌株（41%）具有相同的谱型，提示存在交叉传播。第三代头孢菌素类洋葱伯克霍尔德菌感染与高死亡率相关（p = 0.01）。
