一群意大利囊性纤维化患者中的洋葱伯克霍尔德菌复合群感染
Burkholderia cepacia complex infection in a cohort of Italian patients with cystic fibrosis.
作者信息
Lambiase Antonietta, Raia Valeria, Stefani Stefania, Sepe Angela, Ferri Pasqualina, Buonpensiero Paolo, Rossano Fabio, Del Pezzo Mariassunta
机构信息
Department of Biology and Pathology, Luigi Califano, University of Naples Federico II, Italy.
出版信息
J Microbiol. 2007 Jun;45(3):275-9.
The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01).
本研究的目的是在一组囊性纤维化患者（n = 276）中检测洋葱伯克霍尔德菌复合体（Bcc）菌株，并通过分子技术对Bcc分离株进行特征分析。结果显示，11.23%的患者感染了Bcc。第三代头孢菌素类洋葱伯克霍尔德菌III-A型是最常见的菌种（64.3%），其中，10%为cblA阳性，50%为esmR阳性。不到一半的菌株对头孢他啶、美罗培南、哌拉西林他唑巴坦和复方新诺明敏感。约一半的菌株（41%）具有相同的谱型，提示存在交叉传播。第三代头孢菌素类洋葱伯克霍尔德菌感染与高死亡率相关（p = 0.01）。
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