生长受限胎儿和婴儿未来大脑皮质中的严重细胞减少。
Severe cell reduction in the future brain cortex in human growth-restricted fetuses and infants.
作者信息
Samuelsen Grethe B, Pakkenberg Bente, Bogdanović Nenad, Gundersen Hans J G, Larsen Jørgen Falck, Graem Niels, Laursen Henning
机构信息
Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, Copenhagen, Denmark.
出版信息
Am J Obstet Gynecol. 2007 Jul;197(1):56.e1-7. doi: 10.1016/j.ajog.2007.02.011.
OBJECTIVE
The objective of the study was to test the hypothesis that the total number of cells in the cortical part of the cerebral wall is the same in intrauterine growth-restricted (IUGR) fetuses, compared with normally grown fetuses.
STUDY DESIGN
The total cell number in the cerebral wall was estimated in 9 severely affected IUGR fetuses and 15 controls using the optical fractionator. Cell numbers were estimated within 4 developmental zones. The gestational ages were 19-41 weeks.
RESULTS
The total cell number in the future cortex was significantly reduced in the IUGR fetuses, compared with controls. The daily increase in brain cells in the future cortex was only half of that of the controls. In the 3 other developmental zones, no significant differences in cell numbers could be demonstrated.
CONCLUSIONS
IUGR in humans is associated with a severe reduction in cortical growth and a significant decrease in cell number in the future cortex.
目的
本研究的目的是检验以下假设：与正常生长的胎儿相比，宫内生长受限（IUGR）胎儿脑壁皮质部分的细胞总数相同。
研究设计
使用光学分割器对9例严重受影响的IUGR胎儿和15例对照胎儿的脑壁细胞总数进行估计。在4个发育区域内估计细胞数量。胎龄为19 - 41周。
结果
与对照组相比，IUGR胎儿未来皮质中的细胞总数显著减少。未来皮质中脑细胞的每日增加量仅为对照组的一半。在其他3个发育区域，细胞数量未显示出显著差异。
结论
人类宫内生长受限与皮质生长严重减少以及未来皮质中细胞数量显著减少有关。
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