Foster Raymond T, Barber Matthew D, Parasio Marie Fidela R, Walters Mark D, Weidner Alison C, Amundsen Cindy L
Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA.
Am J Obstet Gynecol. 2007 Jul;197(1):82.e1-4. doi: 10.1016/j.ajog.2007.02.049.
The objective of this study was to evaluate the impact of transvaginal prolapse surgery on overactive bladder symptoms in elderly women.
Women (> or = 65 years old) with stage III or IV prolapse who enrolled in a prospective study that compared vaginal reconstructive surgery (n = 39) to obliterative surgery (n = 26) and who underwent preoperative urodynamics are the subjects of this study. The women completed the Pelvic Floor Distress Inventory at baseline and again 6 months and 12 months after surgery. Postoperative changes in symptoms of urinary urgency, frequency, and urge urinary incontinence were assessed. The association between a baseline urodynamic diagnosis of detrusor overactivity and pre- and postoperative overactive bladder symptoms was also determined.
Data were analyzed from 65 subjects with a mean age of 75.3 years (range, 65.5-87.0 years). Detrusor overactivity was documented in 25% of subjects. There was no difference in the proportion of baseline urge incontinence (P = .38), urinary frequency (P = .53), or urgency (P = .76) in comparing women with and without detrusor overactivity. Surgery resulted in a significant reduction of urgency and frequency symptoms 6 months after surgery and a similar significant reduction in urgency and urge incontinence at 1 year after surgery. Overall, a clinically and statistically significant improvement in the irritative subscale of the Pelvic Floor Distress Inventory was noted at 6 months (18.3%; P < .0001) and 12 months (17.6%; P < .0001) after surgery. In our cohort, performance of a mid urethral sling, a bladder neck sling, or a Kelly plication was not associated with a reduction in postoperative symptoms of urgency, frequency, or urge incontinence (P = .48). Likewise, there was no difference in postoperative symptom reduction (urgency, frequency, or urge incontinence) between women who received reconstructive surgery vs women who had obliterative surgery (P = .84).
Vaginal surgery for stage III or IV pelvic organ prolapse significantly reduces overactive bladder symptoms in elderly women. In our cohort, symptom reduction was unrelated to the type of vaginal surgery (obliterative vs reconstructive) or the inclusion of a procedure to treat stress incontinence. Furthermore, preoperative urodynamic findings did not correlate with the presence or absence of overactive bladder symptoms.
本研究的目的是评估经阴道脱垂手术对老年女性膀胱过度活动症症状的影响。
本研究的对象为年龄≥65岁、患有III期或IV期脱垂且参与了一项前瞻性研究的女性,该研究比较了阴道重建手术(n = 39)和封闭性手术(n = 26),且这些女性均接受了术前尿动力学检查。这些女性在基线时、术后6个月和12个月时完成盆底困扰量表调查。评估术后尿急、尿频和急迫性尿失禁症状的变化。还确定了基线时逼尿肌过度活动的尿动力学诊断与术前和术后膀胱过度活动症症状之间的关联。
对65名平均年龄为75.3岁(范围为65.5 - 87.0岁)的受试者的数据进行了分析。25%的受试者记录有逼尿肌过度活动。在比较有和没有逼尿肌过度活动的女性时,基线时急迫性尿失禁(P = 0.38)、尿频(P = 0.53)或尿急(P = 0.76)的比例没有差异。手术导致术后6个月时尿急和尿频症状显著减轻,术后1年时尿急和急迫性尿失禁也有类似的显著减轻。总体而言,术后6个月(18.3%;P < 0.0001)和12个月(17.6%;P < 0.0001)时,盆底困扰量表的刺激性亚量表在临床和统计学上有显著改善。在我们的队列中,进行尿道中段吊带术、膀胱颈吊带术或凯利折叠术与术后尿急、尿频或急迫性尿失禁症状的减轻无关(P = 0.48)。同样,接受重建手术的女性与接受封闭性手术的女性在术后症状减轻(尿急、尿频或急迫性尿失禁)方面没有差异(P = 0.84)。
III期或IV期盆腔器官脱垂的阴道手术可显著减轻老年女性的膀胱过度活动症症状。在我们的队列中,症状减轻与阴道手术类型(封闭性手术与重建性手术)或是否包含治疗压力性尿失禁的手术无关。此外,术前尿动力学检查结果与膀胱过度活动症症状的有无无关。