Rogowski Artur, Krowicka-Wasyl Maria, Dybowski Bartosz, Sienkiewicz-Jarosz Halina, Wichniak Adam, Samochowiec Jerzy, Wojnar Marcin, Issat Tadeusz, Syrylo Tomasz, Jankiewicz Katarzyna, Bieńkowski Przemysław
Department of Minimally Invasive and Endoscopic Gynecology, Military Institute of Medicine, Legionowo, Poland.
Department of Obstetrics and Gynecology, Mother and Child Institute, Warsaw, Poland.
Cent European J Urol. 2024;77(4):641-648. doi: 10.5173/ceju.2024.0210. Epub 2024 Nov 16.
GABAergic sedative-hypnotics, including benzodiazepines (BDZs) and Z-drugs, are some of the most used and misused psychotropic medications in developed countries. Growing evidence points to the role of psychiatric comorbidities in overactive bladder (OAB) and in urge urinary incontinence. The aim of the present study was to evaluate: 1) the prevalence of BDZs and/or Z-drugs use in female OAB patients, 2) the risk of dependence on BDZs and/or Z-drugs in female OAB patients, 3) the relationship between the use of BDZs and/or Z-drugs and the severity of OAB symptoms.
The prevalence of BDZs and/or Z-drugs use, the risk of dependence on BDZs and/or Z-drugs, and the relationship between the use of BDZs and/or Z-drugs and the severity of OAB symptoms was assessed in OAB patients recruited in the urogynecological outpatient clinic.
A higher percentage of OAB patients confirmed the use of GABAergic sedative-hypnotics in the last 12 months as compared to the non-OAB outpatients presenting for routine gynecological prophylaxis. A larger number of OAB patients (5.6%) met the diagnosis of lifetime BDZ (and/or Z-drug) dependence as compared to the controls (0.9%). The use of sedative-hypnotics did not correlate with OAB symptoms.
Our results suggest that the use of and dependence on GABAergic sedative-hypnotics may be associated with the OAB diagnosis in female urogynecological patients.
γ-氨基丁酸能镇静催眠药，包括苯二氮䓬类药物（BDZs）和Z类药物，是发达国家使用最广泛且滥用情况最严重的精神药物之一。越来越多的证据表明精神共病在膀胱过度活动症（OAB）和急迫性尿失禁中起作用。本研究的目的是评估：1）女性OAB患者中BDZs和/或Z类药物的使用 prevalence，2）女性OAB患者对BDZs和/或Z类药物产生依赖的风险，3）BDZs和/或Z类药物的使用与OAB症状严重程度之间的关系。
在泌尿妇科门诊招募的OAB患者中，评估了BDZs和/或Z类药物的使用 prevalence、对BDZs和/或Z类药物产生依赖的风险，以及BDZs和/或Z类药物的使用与OAB症状严重程度之间的关系。
与因常规妇科预防前来就诊的非OAB门诊患者相比，更高比例的OAB患者确认在过去12个月内使用过γ-氨基丁酸能镇静催眠药。与对照组（0.9%）相比，更多的OAB患者（5.6%）符合终生BDZ（和/或Z类药物）依赖的诊断。镇静催眠药的使用与OAB症状无关。
我们的结果表明，γ-氨基丁酸能镇静催眠药的使用和依赖可能与女性泌尿妇科患者的OAB诊断有关。
