肿瘤大小是可切除胃肠道间质瘤患者复发的主要决定因素。
Tumor size is a major determinant of recurrence in patients with resectable gastrointestinal stromal tumor.
作者信息
Hsu Kai-Hsi, Yang Ta-Ming, Shan Yan-Shen, Lin Pin-Wen
机构信息
Department of Surgery, Tainan Hospital, Department of Health, Executive Yuan, 125, Jhong-Shan Rd, Tainan 700, Taiwan, ROC.
出版信息
Am J Surg. 2007 Aug;194(2):148-52. doi: 10.1016/j.amjsurg.2006.10.033.
BACKGROUND
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract. Surgery remains the mainstay of curative treatment. Recurrence after surgery was frequent and was associated with poor prognosis. In this study, we tried to identify predictors of recurrence in resectable GISTs.
METHODS
Between January 1995 and December 2005, 100 patients undergoing surgical resection for GISTs in 2 hospitals were studied.
RESULTS
There were 67 gastric and 33 intestinal GISTs. Recurrence was noted in 11 patients (median follow-up of 43 months). Overall 5-year survival was 84%. Multivariate analysis demonstrated that tumor size > or = 10 cm was associated with higher recurrence rates (P = .032) and was the only independent poor prognostic factor for survival (P = .020).
CONCLUSIONS
We concluded that tumor size > or = 10 cm carried both a higher risk of recurrence and worse survival in resectable GISTs and could be considered an indicator for adjuvant therapy.
背景
胃肠道间质瘤（GISTs）是胃肠道最常见的间叶组织肿瘤。手术仍然是根治性治疗的主要手段。术后复发很常见，且与预后不良相关。在本研究中，我们试图确定可切除GISTs复发的预测因素。
方法
1995年1月至2005年12月期间，对2家医院100例行GISTs手术切除的患者进行了研究。
结果
有67例胃GISTs和33例肠GISTs。11例患者出现复发（中位随访43个月）。总体5年生存率为84%。多因素分析表明，肿瘤大小≥10 cm与较高的复发率相关（P = 0.032），并且是生存的唯一独立不良预后因素（P = 0.020）。
结论
我们得出结论，在可切除的GISTs中，肿瘤大小≥10 cm具有较高的复发风险和较差的生存率，可被视为辅助治疗的指标。
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