受损脊髓的再髓鞘化。
Remyelination of the injured spinal cord.
作者信息
Sasaki Masanori, Li Bingcang, Lankford Karen L, Radtke Christine, Kocsis Jeffery D
机构信息
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA, and Research Institute of Surgery, Daping Hospital, Chongqing, P.R. China.
出版信息
Prog Brain Res. 2007;161:419-33. doi: 10.1016/S0079-6123(06)61030-3.
Abstract
Contusive spinal cord injury (SCI) can result in necrosis of the spinal cord, but often long white matter tracts outside of the central necrotic core are demyelinated. One experimental strategy to improve functional outcome following SCI is to transplant myelin-forming cells to remyelinate these axons and improve conduction. This review focuses on transplantation studies using olfactory ensheathing cell (OEC) to improve functional outcome in experimental models of SCI and demyelination. The biology of the OEC, and recent experimental research and clinical studies using OECs as a potential cell therapy candidate are discussed.
摘要
挫伤性脊髓损伤（SCI）可导致脊髓坏死，但中央坏死核心之外的长白质束常发生脱髓鞘。改善脊髓损伤后功能转归的一种实验策略是移植形成髓鞘的细胞，使这些轴突重新髓鞘化并改善传导。本综述重点关注使用嗅鞘细胞（OEC）进行移植研究，以改善脊髓损伤和脱髓鞘实验模型中的功能转归。文中讨论了嗅鞘细胞的生物学特性，以及最近将嗅鞘细胞用作潜在细胞治疗候选物的实验研究和临床研究。
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