Lortie Mireille, Beanlands Rob S B, Yoshinaga Keiichiro, Klein Ran, Dasilva Jean N, DeKemp Robert A
Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St., Ottawa, ON K1Y 4W7, Canada.
Eur J Nucl Med Mol Imaging. 2007 Nov;34(11):1765-74. doi: 10.1007/s00259-007-0478-2. Epub 2007 Jul 7.
The PET tracer (82)Rb is commonly used to evaluate regional perfusion defects for the diagnosis of coronary artery disease. There is limited information on the quantification of myocardial blood flow and flow reserve with this tracer. The goal of this study was to investigate the use of a one-compartment model of (82)Rb kinetics for the quantification of myocardial blood flow.
Fourteen healthy volunteers underwent rest and dipyridamole stress imaging with both (13)N-ammonia and (82)Rb within a 2-week interval. Myocardial blood flow was estimated from the time-activity curves measured with (13)N-ammonia using a standard two-compartment model. The uptake parameter of the one-compartment model was estimated from the time-activity curves measured with (82)Rb. To describe the relationship between myocardial blood flow and the uptake parameter, a nonlinear extraction function was fitted to the data. This function was then used to convert estimates of the uptake parameter to flow estimates. The extraction function was validated with an independent data set obtained from 13 subjects with documented evidence of coronary artery disease (CAD).
The one-compartment model described (82)Rb kinetics very well (median R-square = 0.98). The flow estimates obtained with (82)Rb were well correlated with those obtained with (13)N-ammonia (r = 0.85), and the best-fit line did not differ significantly from the identity line. Data obtained from the subjects with CAD confirmed the validity of the estimated extraction function.
It is possible to obtain accurate estimates of myocardial blood flow and flow reserve with a one-compartment model of (82)Rb kinetics and a nonlinear extraction function.
正电子发射断层显像（PET）示踪剂（82）Rb常用于评估区域灌注缺损以诊断冠状动脉疾病。关于使用该示踪剂定量心肌血流量和血流储备的信息有限。本研究的目的是探讨使用（82）Rb动力学的单室模型来定量心肌血流量。
14名健康志愿者在2周内先后接受了静息和双嘧达莫负荷状态下的（13）N-氨和（82）Rb显像。使用标准双室模型根据（13）N-氨测量的时间-活性曲线估算心肌血流量。单室模型的摄取参数根据（82）Rb测量的时间-活性曲线估算。为描述心肌血流量与摄取参数之间的关系，对数据拟合了非线性提取函数。然后使用该函数将摄取参数的估算值转换为血流估算值。利用从13名有冠状动脉疾病（CAD）记录证据的受试者获得的独立数据集对提取函数进行验证。
单室模型很好地描述了（82）Rb的动力学（中位数决定系数R² = 0.98）。（82）Rb获得的血流估算值与（13）N-氨获得的血流估算值高度相关（r = 0.85），最佳拟合线与恒等线无显著差异。从CAD受试者获得的数据证实了估算的提取函数的有效性。
使用（82）Rb动力学的单室模型和非线性提取函数能够准确估算心肌血流量和血流储备。
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