Schäfers Klaus P, Spinks Terence J, Camici Paolo G, Bloomfield Peter M, Rhodes Christopher G, Law Marilyn P, Baker Christopher S R, Rimoldi Ornella
Medical Research Council Clinical Sciences Centre and National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, United Kingdom.
J Nucl Med. 2002 Aug;43(8):1031-40.
The purpose of this study was to assess a 3-dimensional (3D)-only PET scanner (ECAT EXACT3D) for its use in the absolute quantification of myocardial blood flow (MBF) using H(2)(15)O.
Nine large white pigs were scanned with H(2)(15)O and C(15)O before and after partially occluding the circumflex (n = 4) or the left anterior descending (n = 5) coronary artery at rest and during hyperemia induced by intravenous dipyridamole. Radioactive microspheres labeled with either (57)Co or (46)Sc were injected during each of the H(2)(15)O scans, which allowed comparison between microsphere and PET measurements of regional MBF. PET analyses of 3D acquisition data were performed using filtered backprojection reconstruction and region-of-interest definition by factor and cluster analysis techniques and single-compartment model quantification.
The Hanning filter applied in image reconstruction resulted in a left atrial blood volume recovery factor of 0.84 +/- 0.06. Differences between repeated measurements of recovery were small (mean, -0.8%; range, -6.6% to 3.6%). In 256 paired measurements of MBF ranging from 0.05 to 4.4 mL. g(- 1). min(-1), microsphere and PET measurements were fairly well correlated. The mean difference between the 2 methods was - 0.11 mL. g(-1). min(-1) and the limits of agreement (+2 SD) were -0.82 and 0.60 mL. g(-1). min(-1) (Bland-Altman plot).
Dynamic measurements with H(2)(15)O using a 3D-only PET tomograph provide reliable and accurate measurements of absolute regional MBF over a wide flow range. The 3D acquisition technique can reduce the radiation dose to the subject while maintaining adequate counting statistics.
本研究的目的是评估一种仅具备三维（3D）功能的正电子发射断层扫描仪（ECAT EXACT3D）在使用H₂¹⁵O进行心肌血流量（MBF）绝对定量分析中的应用。
9只大型白色猪在静息状态以及静脉注射双嘧达莫诱发充血期间，在左旋支（n = 4）或左前降支（n = 5）冠状动脉部分闭塞前后，分别用H₂¹⁵O和C¹⁵O进行扫描。在每次H₂¹⁵O扫描期间注射用⁵⁷Co或⁴⁶Sc标记的放射性微球，这使得能够对区域MBF的微球测量值和PET测量值进行比较。使用滤波反投影重建以及通过因子和聚类分析技术进行感兴趣区定义和单室模型定量分析，对3D采集数据进行PET分析。
图像重建中应用的汉宁滤波器使得左心房血容量恢复因子为0.84±0.06。恢复的重复测量之间的差异较小（平均值为 -0.8%；范围为 -6.6%至3.6%）。在256对MBF测量值范围为0.05至4.4 mL·g⁻¹·min⁻¹的配对测量中，微球测量值和PET测量值具有较好的相关性。两种方法之间的平均差异为 -0.11 mL·g⁻¹·min⁻¹，一致性界限（+2 SD）为 -0.82和0.60 mL·g⁻¹·min⁻¹（布兰德 - 奥特曼图）。
使用仅具备3D功能的PET断层扫描仪进行H₂¹⁵O动态测量，可在较宽的血流范围内提供可靠且准确的绝对区域MBF测量值。3D采集技术可在保持足够计数统计量的同时降低受试者的辐射剂量。
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