Hussain Zahid, Harrison Simon C W
Department of Urology, Pinderfields General Hospital, Wakefield, UK.
ScientificWorldJournal. 2007 Jun 22;7:1036-45. doi: 10.1100/tsw.2007.173.
The aim of this review is to provide an update on the use of neuromodulation using sacral nerve stimulation for the treatment of disorders of the lower urinary tract. Neuromodulation using the InterStim system (Medtronic Inc.) is now accepted as an established therapeutic option for patients with detrusor overactivity, and for women with retention or severe voiding difficulties. However, the use of nerve stimulation in modulating lower urinary tract function has to be regarded as a technique that is in its infancy. Much has yet to be learned about the mechanism by which neuromodulation exerts its effects and there is a need to better define the clinical indications for the treatment. There is also work to be done in terms of optimising stimulation delivery, both in anatomical and electronic terms.
本综述的目的是提供关于使用骶神经刺激进行神经调节治疗下尿路疾病的最新情况。使用InterStim系统（美敦力公司）进行神经调节现已被公认为治疗逼尿肌过度活动患者以及患有尿潴留或严重排尿困难的女性的既定治疗选择。然而，神经刺激在调节下尿路功能方面的应用仍被视为一项尚处于起步阶段的技术。关于神经调节发挥作用的机制仍有许多有待了解之处，并且需要更好地界定该治疗的临床适应症。在优化刺激传递方面，无论是在解剖学还是电子学方面，都还有工作要做。
