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5-羟色胺受体在肠道传入神经上对内脏敏感性调节的重要性。

Importance of 5-hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity.

作者信息

Greenwood-van Meerveld B

机构信息

Veteran's Affairs Medical Center and Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.

出版信息

Neurogastroenterol Motil. 2007 Aug;19 Suppl 2:13-8. doi: 10.1111/j.1365-2982.2007.00964.x.

DOI:10.1111/j.1365-2982.2007.00964.x
PMID:17620083
Abstract

Serotonin (5-HT) plays an important role as a signalling molecule in the gastrointestinal (GI) tract. The regulation of GI sensitivity via 5-HT is mediated by specific 5-HT receptor subytypes on intrinsic and extrinsic afferents. This review discusses visceral afferent hypersensitivity in irritable bowel syndrome (IBS) and the importance of 5HT(3), 5HT(4), and 5HT(2B) receptor-mediated mechanisms in the regulation of visceral sensitivity.

摘要

血清素（5-羟色胺，5-HT）作为一种信号分子在胃肠道中发挥着重要作用。5-HT对胃肠道敏感性的调节是由内在和外在传入神经上特定的5-HT受体亚型介导的。本文综述了肠易激综合征（IBS）中的内脏传入神经超敏反应以及5HT(3)、5HT(4)和5HT(2B)受体介导的机制在调节内脏敏感性中的重要性。

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