肺癌患者血液中的P53和MDM2亚型

P53 and MDM2 isoforms in blood from lung cancer patients.

作者信息

Gonzalez-Avila Georgina, Biol Javier Delgado, Martínez Luis M, Ramos Carlos, Sommer Bettina

机构信息

Extracellular Matrix Laboratory, Department of Chronic Degenerative Diseases, Instituto Nacional de Enfermedades Respiratorias, México.

出版信息

Exp Lung Res. 2007 Jun-Jul;33(5):245-58. doi: 10.1080/01902140701481112.

DOI:10.1080/01902140701481112

PMID:17620186

Abstract

The present study was designed to detect changes in p53 and MDM2 protein expression patterns in plasma from lung cancer patients. The largest p53 protein expression was observed in adenocarcinoma patients; however, mutant p53 was not increased in any cancer sample. A significant increase in the 57-kDa MDM2 isoform was observed in adenocarcinoma patients with low protein expression of the 90-kDa isoform. Our findings suggest that p53 accumulation could be due to a decrease in full-length MDM2 isoform together with an increase of the 57-kDa MDM2 isoform that was unable to stimulate p53 degradation.

摘要

本研究旨在检测肺癌患者血浆中p53和MDM2蛋白表达模式的变化。在腺癌患者中观察到最大的p53蛋白表达；然而，在任何癌症样本中突变型p53均未增加。在90-kDa亚型蛋白表达较低的腺癌患者中，观察到57-kDa MDM2亚型显著增加。我们的研究结果表明，p53积累可能是由于全长MDM2亚型减少，以及无法刺激p53降解的57-kDa MDM2亚型增加所致。