一种新型聚合胍在耐甲氧西林金黄色葡萄球菌实验性皮肤感染中的体内活性
In vivo activity of a novel polymeric guanidine in experimental skin infection with methicillin-resistant Staphylococcus aureus.
作者信息
Kratzer Christina, Tobudic Selma, Macfelda Karin, Graninger Wolfgang, Georgopoulos Apostolos
机构信息
Department of Internal Medicine I, Division of Infectious Diseases and Chemotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
出版信息
Antimicrob Agents Chemother. 2007 Sep;51(9):3437-9. doi: 10.1128/AAC.00130-07. Epub 2007 Jul 9.
Abstract
The in vivo efficacy of the novel polymeric guanidine AKACID Plus was evaluated in a guinea pig model of experimental skin infection with methicillin-resistant Staphylococcus aureus (MRSA). Topical application of AKACID Plus at concentrations of > or =0.5% was as effective as mupirocin 2% cream in the treatment of superficial skin infection with MRSA.
摘要
新型聚合胍AKACID Plus在耐甲氧西林金黄色葡萄球菌（MRSA）实验性皮肤感染的豚鼠模型中进行了体内疗效评估。浓度≥0.5%的AKACID Plus局部应用在治疗MRSA浅表皮肤感染方面与2%莫匹罗星乳膏效果相当。
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