Krishnam Mayil S, Suh Robert D, Tomasian Anderanik, Goldin Jonathan G, Lai Chi, Brown Kathleen, Batra Poonam, Aberle Denise R
Department of Radiological Sciences, David Geffen School of Medicine, University of California at Los Angeles, Peter V. Ueberroth Bldg, Suite 3371, 10945 LeConte Ave, Los Angeles, CA 90095-7206, USA.
Radiographics. 2007 Jul-Aug;27(4):957-74. doi: 10.1148/rg.274065141.
In the past decade, lung transplantation has become established as an accepted therapy for end-stage pulmonary disease. Complications of lung transplantation that may occur in the immediate or longer postoperative term include mechanical problems due to a size mismatch between the donor lung and the recipient thoracic cage; malposition of monitoring tubes and lines; injuries from ischemia and reperfusion; acute pleural events; hyperacute, acute, and chronic rejection; pulmonary infections; bronchial anastomotic complications; pulmonary thromboembolism; upper-lobe fibrosis; primary disease recurrence; posttransplantation lymphoproliferative disorder; and native lung complications such as hyperinflation, malignancy, and infection. Radiologic imaging--particularly chest radiography, computed tomography (CT), and high-resolution CT--is critical for the early detection, evaluation, and diagnosis of complications after lung transplantation. To enable the selection of an effective and relevant course of therapy and, ultimately, to decrease morbidity and mortality among lung transplant recipients, radiologists at all levels of experience must be able to recognize and understand the imaging manifestations of posttransplantation complications.
在过去十年中,肺移植已成为终末期肺部疾病公认的治疗方法。肺移植术后近期或远期可能出现的并发症包括:供体肺与受体胸廓大小不匹配导致的机械问题;监测管和线路位置不当;缺血和再灌注损伤;急性胸膜事件;超急性、急性和慢性排斥反应;肺部感染;支气管吻合口并发症;肺血栓栓塞;上叶纤维化;原发病复发;移植后淋巴细胞增生性疾病;以及诸如肺过度充气、恶性肿瘤和感染等自体肺并发症。放射影像学——尤其是胸部X线摄影、计算机断层扫描(CT)和高分辨率CT——对于肺移植术后并发症的早期检测、评估和诊断至关重要。为了能够选择有效的相关治疗方案,并最终降低肺移植受者的发病率和死亡率,各级经验的放射科医生必须能够识别和理解移植后并发症的影像学表现。