Galletti Ferruccio, Barbato Antonio, Versiero Marco, Iacone Roberto, Russo Ornella, Barba Gianvincenzo, Siani Alfonso, Cappuccio Francesco P, Farinaro Eduardo, della Valle Elisabetta, Strazzullo Pasquale
Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy.
J Hypertens. 2007 Aug;25(8):1671-7. doi: 10.1097/HJH.0b013e3281afa09e.
Because high circulating plasma leptin is associated with many features of the metabolic syndrome (MS), such as abdominal obesity, insulin resistance and high blood pressure (BP), we analysed the ability of plasma leptin concentration to predict the risk of developing MS in a prospective investigation of adult male participants of the Olivetti Heart Study (OHS).
Three hundred and sixty out of 907 men participating in the 1994-95 and 2002-04 OHS examinations (mean age at baseline 50.4 years, range 25-73 years) were free of MS at first visit according to NCEP-ATP III criteria (modified for the lack of high-density lipoprotein cholesterol measurement at baseline). During an average follow-up period of 8 years, there were 52 incident cases of MS (14.5%) due, in particular, to a rise in the prevalence of high BP (+42.4%), abdominal obesity (+16.4%) and impaired fasting glucose (IFG, +6.1%). In multivariate analyses, a one standard deviation difference in baseline plasma leptin concentration was associated with a 1.58-fold greater risk of developing MS (95% confidence interval = 1.10-2.30, P = 0.016) accounting for age, waist circumference, homeostatic assessment model index, smoking, alcohol consumption and physical activity. In particular, plasma leptin was positively associated with the risk of developing high BP (0.006) and IFG (0.014), after adjustment for confounders.
In this sample of an adult male population free of MS at baseline, circulating plasma leptin was a significant predictor of the risk of MS and, in particular, of its high BP and IFG components, independently of potential confounders.
由于循环血浆瘦素水平升高与代谢综合征（MS）的许多特征相关，如腹型肥胖、胰岛素抵抗和高血压（BP），我们在一项针对奥利维蒂心脏研究（OHS）成年男性参与者的前瞻性调查中，分析了血浆瘦素浓度预测发生MS风险的能力。
907名参与1994 - 1995年及2002 - 2004年OHS检查的男性中（基线时平均年龄50.4岁，范围25 - 73岁），根据NCEP - ATP III标准（因基线时缺乏高密度脂蛋白胆固醇测量而修改），360名男性在首次就诊时无MS。在平均8年的随访期内，有52例MS新发病例（14.5%），特别是由于高血压患病率上升（+42.4%）、腹型肥胖（+16.4%）和空腹血糖受损（IFG，+6.1%）。在多变量分析中，基线血浆瘦素浓度每相差一个标准差，发生MS的风险就高1.58倍（95%置信区间 = 1.10 - 2.30，P = 0.016），该分析考虑了年龄、腰围、稳态评估模型指数、吸烟、饮酒和身体活动。特别是，在调整混杂因素后，血浆瘦素与发生高血压（0.006）和IFG（0.014）的风险呈正相关。
在这个基线时无MS的成年男性样本中，循环血浆瘦素是MS风险的重要预测指标，尤其是其高血压和IFG组分的风险指标，独立于潜在的混杂因素。
