Barreiro Elena, Casas José S, Couce María D, Sánchez Agustín, Seoane Rafael, Sordo José, Varela José M, Vázquez-López Ezequiel M
Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain.
Dalton Trans. 2007 Jul 28(28):3074-85. doi: 10.1039/b702936e. Epub 2007 May 22.
We have investigated the reactions of silver nitrate and 3-(aryl)-2-sulfanylpropenoic acids [H(2)xspa, x: p = 3-phenyl-, f = 3-(2-furyl)-, t = 3-(2-thienyl)-, py = 3-(2-pyridyl)-] and 2-cyclopentylidene-2-sulfanylacetic acid (H(2)L) in 1 : 1 and 2 : 1 molar ratios. The 1 : 1 molar ratio gave compounds of type [Ag(HL)]; reaction of these compounds with diisopropylamine and NaOH gave [HQ][Ag(L)] (HQ = diisopropylammonium) and Na[Ag(L)] x H(2)O, respectively. These compounds, as well as those of type [Ag(2)(L)] obtained with the 1 : 2 molar ratio, were isolated and characterized by IR and NMR ((1)H and (13)C) spectroscopy. (109)Ag NMR spectroscopy and ESI-MS spectrometry were also used in some cases. The crystal structures of [HQ][Ag(pspa)] (11), in which the presence of structural isomers was detected, and [HQ][Ag(cpa)] (15) were determined by X-ray diffractometry. The antimicrobial activity of the complexes against E. coli, S. aureus, B. subtilis, P. aeruginosa/Resistant P. aeruginosa, and C. albicans was tested.
我们研究了硝酸银与3 -（芳基）-2 - 硫代丙烯酸[H(2)xspa，x：p = 3 - 苯基 - ，f = 3 -（2 - 呋喃基）- ，t = 3 -（2 - 噻吩基）- ，py = 3 -（2 - 吡啶基）- ]以及2 - 环亚戊基 - 2 - 硫代乙酸（H(2)L）以1:1和2:1摩尔比的反应。1:1摩尔比生成了[Ag(HL)]型化合物；这些化合物与二异丙胺和氢氧化钠反应分别生成了[HQ][Ag(L)]（HQ = 二异丙铵）和Na[Ag(L)]·H(2)O。这些化合物以及以1:2摩尔比得到的[Ag(2)(L)]型化合物均被分离出来，并通过红外光谱和核磁共振（(1)H和(13)C）光谱进行了表征。在某些情况下还使用了(109)Ag核磁共振光谱和电喷雾电离质谱。通过X射线衍射测定了检测到结构异构体存在情况的[HQ][Ag(pspa)]（11）和[HQ][Ag(cpa)]（15）的晶体结构。测试了这些配合物对大肠杆菌、金黄色葡萄球菌、枯草芽孢杆菌、铜绿假单胞菌/耐药铜绿假单胞菌以及白色念珠菌的抗菌活性。
