台湾痴呆症患者白细胞介素-1α和-1β启动子多态性
Interleukin-1alpha and -1beta promoter polymorphisms in Taiwanese patients with dementia.
作者信息
Wang Hsiu-Kuan, Hsu Wen-Chuin, Fung Hon-Chung, Lin Jun-Cheng, Hsu Hai-Pei, Wu Yih-Ru, Hsu Yuying, Hu Fen-Ju, Lee-Chen Guey-Jen, Chen Chiung-Mei
机构信息
Department of Life Science, National Taiwan Normal University, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan, ROC.
出版信息
Dement Geriatr Cogn Disord. 2007;24(2):104-10. doi: 10.1159/000104829. Epub 2007 Jun 29.
BACKGROUND
Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1alpha -889 C/T and IL-1beta -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD).
METHODS
AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls (n = 209) were analyzed by means of genotype association method.
RESULTS
No significant difference in the genotype distribution of the analyzed single nucleotide polymorphisms was found between AD or VaD cases and controls. However, the frequency of the IL-1alpha -889 CT genotype was notably lower in VaD patients aged over 70 years than the age-matched controls (9.1 vs. 22.9%, p = 0.036) andtheIL-1alpha -889 CT genotype demonstrated a trend toward decrease in risk of developing VaD (odds ratio: 0.34; 95% confidence interval: 0.12-0.83, p = 0.026). Multivariate analysis revealed that the IL-1beta -511T-carrying genotype slightly strengthens the negative association of the IL-1alpha -889 CT genotype with VaD (odds ratio: 0.26; 95% confidence interval: 0.08-0.79, p = 0.024).
CONCLUSION
Our data suggest a protective role of the IL-1alpha -889 CT genotype in VaD susceptibility among Taiwanese aged over 70 years.
背景
炎症事件可能参与痴呆症的发病机制，白细胞介素-1（IL-1）可能具有神经毒性和神经保护作用。我们研究了IL-1α -889 C/T和IL-1β -511 C/T启动子多态性是否与阿尔茨海默病（AD）和血管性痴呆（VaD）的风险相关。
方法
采用基因型关联方法分析了符合NINCDS-ADRDA和NINDS-AIREN标准的AD患者（n = 219）、VaD患者（n = 82）以及种族匹配的非痴呆对照者（n = 209）。
结果
在AD或VaD病例与对照者之间，所分析的单核苷酸多态性的基因型分布没有显著差异。然而，70岁以上的VaD患者中IL-1α -889 CT基因型的频率显著低于年龄匹配的对照者（9.1%对22.9%，p = 0.036），并且IL-1α -889 CT基因型显示出患VaD风险降低的趋势（优势比：0.34；95%置信区间：0.12 - 0.83，p = 0.026）。多变量分析显示，携带IL-1β -511T的基因型略微增强了IL-1α -889 CT基因型与VaD的负相关（优势比：0.26；95%置信区间：0.08 - 0.79，p = 0.024）。
结论
我们的数据表明，IL-1α -889 CT基因型在台湾70岁以上人群的VaD易感性中具有保护作用。
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