全氟辛烷磺酸氟化物制造工人的自我报告医疗状况。
Self-reported medical conditions in perfluorooctanesulfonyl fluoride manufacturing workers.
作者信息
Grice Mira M, Alexander Bruce H, Hoffbeck Richard, Kampa Diane M
机构信息
University of Minnesota, School of Public Health, Division of Environmental Health Sciences, Minneapolis, Minnesota 55455, USA.
出版信息
J Occup Environ Med. 2007 Jul;49(7):722-9. doi: 10.1097/JOM.0b013e3180582043.
OBJECTIVE
To evaluate whether some cancers, other conditions, and pregnancy outcomes were related to occupational perfluorooctane sulfonate (PFOS) exposure.
METHODS
We surveyed current and former employees of a perfluorooctanesulfonyl fluoride production facility, using a self-administered questionnaire to ascertain several cancers and health conditions. Female cohort members also completed a brief pregnancy history. We requested medical records to validate reported melanoma, breast, prostate, and colon cancers. PFOS exposure was estimated based on a job exposure matrix up to the year of the diagnosis of the condition.
RESULTS
Of the 1,895 eligible participants, 1,400 questionnaires were returned. No association was observed between working in a PFOS-exposed job and the risk of any of the surveyed conditions.
CONCLUSION
We observed no association between working in a PFOS-exposed job and several cancers, common health conditions, and birth weight.
目的
评估某些癌症、其他疾病及妊娠结局是否与职业性全氟辛烷磺酸（PFOS）暴露有关。
方法
我们对一家全氟辛基磺酰氟生产设施的现任和前任员工进行了调查，使用自填式问卷来确定几种癌症和健康状况。女性队列成员还填写了简短的妊娠史。我们要求查阅医疗记录以验证报告的黑色素瘤、乳腺癌、前列腺癌和结肠癌。根据疾病诊断年份之前的工作暴露矩阵估算PFOS暴露情况。
结果
在1895名符合条件的参与者中，共收回1400份问卷。未观察到从事PFOS暴露工作与任何被调查疾病的风险之间存在关联。
结论
我们未观察到从事PFOS暴露工作与几种癌症、常见健康状况及出生体重之间存在关联。
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