Nguyen Yen Thi, Demoulin Bruno, Schweitzer Cyril, Bonabel-Chone Claude, Marchal François
Service d'Explorations Fonctionnelles Pédiatriques, Hôpital d'Enfants, Centre Hospitalier Universitaire de Nancy, F-54511 Vandoeuvre les Nancy, France.
Pediatr Res. 2007 Sep;62(3):348-52. doi: 10.1203/PDR.0b013e3180db2933.
The upper airway wall motion may be responsible for significant error when measuring respiratory resistance (Rrs) with the forced oscillation technique (FOT), particularly in young children with airway obstruction. Assessing the response to methacholine from the change in respiratory admittance (Ars, the reciprocal of respiratory impedance, Zrs) avoids the artifact. The aim of the study was to explore the possibility of assessing the response to a bronchodilator from the change in Ars. FOT measurements were performed at 12 Hz in 36 young children before and after salbutamol. Transrespiratory pressure was varied in two ways: directly at the mouth (standard generator, SG) and around the head (head generator, HG), a variant nearly free of upper airway artifact. Salbutamol induced significantly lower Rrs and Zrs change with SG than HG (respectively, p = 0.0003 and 0.05). The relative change in Ars was not significantly different with SG and HG. Both estimates were significantly correlated (p < 0.0001). The change in Ars may thus be useful to avoid the upper airway artefact when assessing the response to salbutamol using the FOT in young children.
在使用强迫振荡技术（FOT）测量呼吸阻力（Rrs）时，上气道壁运动可能会导致显著误差，尤其是在患有气道阻塞的幼儿中。通过评估呼吸导纳（Ars，呼吸阻抗Zrs的倒数）对乙酰甲胆碱的反应可避免这种假象。本研究的目的是探讨从Ars变化评估对支气管扩张剂反应的可能性。在36名幼儿中，在使用沙丁胺醇前后以12 Hz进行FOT测量。经呼吸压力通过两种方式变化：直接在口腔处（标准发生器，SG）和头部周围（头部发生器，HG，一种几乎没有上气道假象的变体）。与HG相比，沙丁胺醇导致SG的Rrs和Zrs变化显著更低（分别为p = 0.0003和0.05）。Ars的相对变化在SG和HG之间无显著差异。两种估计值显著相关（p < 0.0001）。因此，在幼儿中使用FOT评估对沙丁胺醇的反应时，Ars的变化可能有助于避免上气道假象。
