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巴尔干地方性肾病的肾功能、蛋白质排泄及病理学。I. 肾功能。

Renal function, protein excretion and pathology of Balkan endemic nephropathy. I. Renal function.

作者信息

Trnacević S, Halilbasić A, Ferluga D, Plavljanić D, Vizjak A, Duraković H, Habul V, Mesić E, Imamović G, Hranisavljević J

机构信息

Department of Nephrology and Dialysis, University Medical Center, University of Tuzla, Yugoslavia.

出版信息

Kidney Int Suppl. 1991 Nov;34:S49-51.

PMID:1762335
Abstract

Renal function studies were performed on 59 patients who had the clinical criteria for Balkan endemic nephropathy (BEN). They were divided into three groups according to DTPA clearance (DTPA). Group 1, 11 individuals, had a mean age of 41.6 years and DTPA greater than 100 ml/min. Group 2, 20 persons, had a mean age of 49 years and DTPA of 60 to 100 ml/min. Group 3 was made up of 28 people with a DTPA less than 60 ml/min and an average age of 50.4 years. No distinguishing specific or characteristic symptoms of BEN were found in any of the three groups. Anemia was not found to be an early indicator when compared to other forms of progressive renal disease. Proteinuria was minimal and intermittent in all three groups. Maximum concentrating ability was significantly reduced only in the third group. These features do not allow the clinical differentiation of BEN from other chronic progress tubulointerstitial nephropathies. The geographic isolation and familial nature of the disease, associated with minimal proteinuria make BEN a unique entity. Kidney size by ultrasound was decreased in all three groups, suggesting that this may be another early and characteristic feature to BEN.

摘要

对59例符合巴尔干地方性肾病(BEN)临床标准的患者进行了肾功能研究。根据二乙三胺五乙酸清除率(DTPA)将他们分为三组。第一组有11人,平均年龄41.6岁,DTPA大于100毫升/分钟。第二组有20人,平均年龄49岁,DTPA为60至100毫升/分钟。第三组由28人组成,DTPA小于60毫升/分钟,平均年龄50.4岁。在这三组中均未发现BEN的特异性或特征性症状。与其他形式的进行性肾病相比,贫血未被发现是早期指标。三组的蛋白尿均很少且为间歇性。仅第三组的最大浓缩能力显著降低。这些特征无法实现BEN与其他慢性进行性肾小管间质性肾病的临床鉴别。该疾病的地理隔离和家族性特征,以及轻微蛋白尿,使BEN成为一种独特的疾病。三组患者的肾脏超声测量大小均减小,提示这可能是BEN的另一个早期特征性表现。

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