Ristić S, Marić S, Maksimović Z, Marić V, Djukanović L
Department of Physiology, Faculty of Medicine Foča, University of East Sarajevo, Sarajevo, Bosnia and Herzegovina.
Bijeljina Health Center, Bijeljina, The Republic of Srpska, Bosnia and Herzegovina.
Hippokratia. 2015 Oct-Dec;19(4):304-8.
Kidney size may differ between healthy members of Balkan endemic nephropathy (BEN) and non-BEN families. The present study was designed to elucidate this, in comparison with values for BEN patients.
A total of 71 BEN patients (34 males, 64.4 ± 12.0 years), 74 healthy BEN family members (39 males, 49.1 ± 12.2 years), and 59 non-BEN family members (19 males, 49.2 ± 12.3 years) were involved. We measured the longest craniocaudal length and minimal parenchymal thickness on each kidney of all examined subjects using ultrasound.
No significant difference was found between the kidney length of healthy subjects from BEN (11.0 ± 0.8 cm) and non-BEN families (10.9 ± 0.8 cm), but kidneys were significantly longer than in BEN patients (9.9 ± 1.3 cm). Minimal parenchymal thickness was similar in all three groups. When subjects from each group were divided according to estimated glomerular filtration rate (eGFR), kidney length of the healthy groups was significantly longer than in BEN patients both in stage 1 (p =0.039) and stage 2 (p =0.044) of chronic kidney disease. The parental history of BEN was not associated with kidney dimensions, eGFR, or urinary excretion of albumin and alpha1-microglobulin.
Kidneys of BEN patients were significantly shorter than in healthy members of both BEN and non-BEN families, but no difference was found in kidney length and parenchymal thickness between healthy members of BEN and non-BEN families. No significant association was found between parental history of BEN and kidney size and function either in BEN patients or in healthy members from BEN families. Hippokratia 2015; 19 (4): 304-308.
巴尔干地方性肾病（BEN）家族的健康成员与非BEN家族的健康成员之间的肾脏大小可能存在差异。本研究旨在对此进行阐明，并与BEN患者的相关数值进行比较。
共纳入71例BEN患者（34例男性，年龄64.4±12.0岁）、74名健康的BEN家族成员（39例男性，年龄49.1±12.2岁）和59名非BEN家族成员（19例男性，年龄49.2±12.3岁）。我们使用超声测量了所有受试对象每个肾脏的最长头尾径长度和最小实质厚度。
来自BEN家族的健康受试者（11.0±0.8 cm）与非BEN家族的健康受试者（10.9±0.8 cm）的肾脏长度之间未发现显著差异，但肾脏长度显著长于BEN患者（9.9±1.3 cm）。三组的最小实质厚度相似。当根据估计肾小球滤过率（eGFR）对每组受试者进行分组时，在慢性肾脏病1期（p = 0.039）和2期（p = 0.044），健康组的肾脏长度均显著长于BEN患者。BEN的家族病史与肾脏大小、eGFR或白蛋白和α1-微球蛋白的尿排泄量无关。
BEN患者的肾脏明显短于BEN家族和非BEN家族的健康成员，但BEN家族和非BEN家族的健康成员之间在肾脏长度和实质厚度方面未发现差异。在BEN患者或BEN家族的健康成员中，未发现BEN家族病史与肾脏大小和功能之间存在显著关联。《希波克拉底》2015年；19（4）：304 - 308。
