Kos D, Duportail M, D'hooghe Mb, Nagels G, Kerckhofs E
Department of Rehabilitation Research, Vrije Universiteit Brussel, Brussels, Belgium, Department of Occupational Therapy, National MS Centre, Melsbroek, Belgium.
Mult Scler. 2007 Sep;13(8):996-1003. doi: 10.1177/1352458507078392. Epub 2007 Jul 10.
To establish the efficacy of a multidisciplinary fatigue management programme (MFMP) in MS. Method Fifty-one subjects with MS were randomly allocated to group A, who only received the four weeks MFMP, or group B receiving a placebo intervention programme first and the MFMP after 6 months. In both groups, assessment was performed at baseline, 3 weeks and 6 months after the programmes and included Modified Fatigue Impact Scale (MFIS), Fatigue Severity Scale (FSS), MS Self-Efficacy scale (MSSE), Mental Health Inventory (MHI) and Impact on Participation and Autonomy (IPA).
The MFIS showed a significant change over time (F(4,152) = 3.346, P = 0.012), which was similar in both groups (time*group interaction: F(4,152) = 1.094, P = 0.361). A clinically relevant reduction of MFIS score of 10 points or more was found in 17% of individuals following the MFMP, compared to 44% after the placebo intervention programme (P = 0.06). Compared to no intervention, a significant effect of the MFMP after 6 months (P = 0.003) was found in five participants (31%). No significant changes in FSS, MSSE, MHI and IPA, in both groups, were found.
Although an additional effect was found, the multidisciplinary fatigue management programme showed no efficacy in reducing the impact of fatigue compared to a placebo intervention programme.
确定多学科疲劳管理方案（MFMP）对多发性硬化症（MS）的疗效。方法：51名MS患者被随机分为A组，仅接受为期四周的MFMP，或B组，先接受安慰剂干预方案，6个月后再接受MFMP。两组均在基线、方案实施后3周和6个月进行评估，评估内容包括改良疲劳影响量表（MFIS）、疲劳严重程度量表（FSS）、MS自我效能量表（MSSE）、心理健康量表（MHI）以及对参与和自主性的影响（IPA）。
MFIS显示随时间有显著变化（F(4,152) = 3.346，P = 0.012），两组情况相似（时间*组间交互作用：F(4,152) = 1.094，P = 0.361）。接受MFMP后，17%的个体MFIS得分临床相关降低达10分或更多，而接受安慰剂干预方案后这一比例为44%（P = 0.06）。与无干预相比，6个月后MFMP对5名参与者（31%）有显著效果（P = 0.003）。两组的FSS、MSSE、MHI和IPA均未发现显著变化。
尽管发现了额外效果，但与安慰剂干预方案相比，多学科疲劳管理方案在减轻疲劳影响方面未显示出疗效。
