Meyer-Lehnert H, Evers W M, Krück F
Medizinische Universitäts-Poliklinik, Bonn.
Klin Wochenschr. 1991 Oct 31;69(17):797-801. doi: 10.1007/BF01744272.
In an open, randomized study, we investigated the effect of oral potassium chloride (KCl) and of potassium citrate/bicarbonate (K-cit/bic) in 42 patients with hypokalemia (less than or equal to 3.5 mmol/l). In both groups 80 mmol K+ were administered daily. The parameters examined were serum potassium concentration, acid-base status, and urinary electrolyte excretion. Parameters were evaluated on days 0, 2, 4, and 6. With KCl, [K+] increased from 3.2 +/- 0.2 (mean +/- SD) on day 0 to 3.8 +/- 0.4 mmol/l on day 2 (p less than 0.005) and 4.0 +/- 0.5 mmol/l on day 4 (p less than 0.005). On day 6 [K+] was also 4.0 +/- 0.4 mmol/l (p less than 0.005 vs day 0). With K-cit/bic, [K+] increased from 3.2 +/- 0.2 to 3.7 +/- 0.4 on day 2, 3.9 +/- 0.5 on day 4, and 4.1 +/- 0.6 mmol/l on day 6 (all p less than 0.005 vs day 0). The increase of [K+] was not different between the two groups. Blood pH on day 0 was in the normal range in both groups and did not change significantly during the study. There was a decrease of carbon dioxide partial pressure (pCO2) with KCl from 38.7 +/- 4.9 on day 0 to 36.4 +/- 3.6 on day 2 (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
在一项开放性随机研究中，我们调查了口服氯化钾（KCl）和枸橼酸钾/碳酸氢钾（K-cit/bic）对42例低钾血症（血钾浓度≤3.5 mmol/l）患者的影响。两组患者均每日补充80 mmol钾离子。检测的参数包括血清钾浓度、酸碱状态和尿电解质排泄。在第0、2、4和6天对各项参数进行评估。使用KCl时，血钾浓度（[K+]）从第0天的3.2±0.2（均值±标准差）升高至第2天的3.8±0.4 mmol/l（p<0.005），第4天为4.0±0.5 mmol/l（p<0.005）。第6天[K+]为4.0±0.4 mmol/l（与第0天相比，p<0.005）。使用K-cit/bic时，[K+]在第2天从3.2±0.2升高至3.7±0.4，第4天为3.9±0.5，第6天为4.1±0.6 mmol/l（与第0天相比，均p<0.005）。两组间[K+]的升高幅度无差异。两组第0天的血液pH值均在正常范围内，且在研究期间无显著变化。使用KCl时，二氧化碳分压（pCO2）从第0天的38.7±4.9降至第2天的36.4±3.6（p<0.05）。（摘要截选至250字）
