Shinohara Hisaaki, Kurosaki Tomohiro
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa 230-0045.
Subcell Biochem. 2006;40:145-87. doi: 10.1007/978-1-4020-4896-8_10.
Recent evidence indicates that B lymphocytes are instructed continuously by B cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints during their development and humoral immune responses, reinforcing the importance of studies of the BCR signals. One of the best cell lines for these studies is a chicken DT40 B-cell line, because a high propensity of homologous recombination in this cell line allows us to easily take both genetic and biochemical approaches. Here, based upon the recent data, mainly obtained from the DT40 system, we discuss several new aspects on mechanisms by which BCR signals are propagated and modified.
最近的证据表明，B淋巴细胞在其发育和体液免疫反应的几个检查点上不断受到B细胞受体（BCR）信号的指导，以做出关键的细胞命运决定，这强化了对BCR信号研究的重要性。用于这些研究的最佳细胞系之一是鸡DT40 B细胞系，因为该细胞系中同源重组的高倾向性使我们能够轻松采用遗传和生化方法。在此，基于最近主要从DT40系统获得的数据，我们讨论了BCR信号传播和修饰机制的几个新方面。
