Machtens S, Serth J, Meyer A, Kleinhorst C, Ommer K-J, Herbst U, Kieruij M, Boerner A R
Department of Urology and Paediatric Urology, Marienkrankenhaus Bergisch Gladbach gGmbH, Dr. Robert-Koch-Str. 18, 51465 Bergisch Gladbach, Germany.
World J Urol. 2007 Aug;25(4):341-9. doi: 10.1007/s00345-007-0194-3. Epub 2007 Jul 12.
Positron emission tomography (PET) with the use of ((18)F)2-fluoro-D: -2-desoxyglucose (FDG) has been investigated to be a highly sensitive and specific imaging modality in the diagnostic of primary and recurrent tumors and in the control of therapies in numerous non-urologic cancers. The aim of this review is to validate the significance of PET as a diagnostic tool in malignant urological tumors of the small pelvis. A systematic review of the current literature concerning the role of PET for malignant prostate, testicular and bladder tumors was carried out. The data indicate no additional role for PET in comparison with conventional imaging in tumor detection and local staging for prostate, bladder or testicular cancer. Tumor recurrence in prostate cancer seems to be more effectively identified with acetate and choline than with FDG, but this effect is more pronounced with higher PSA values. The value of PET in the identification of metastatic disease in either tumor entity can not be finally outlined as the clinical data are partly missing, controversial or in the process of evaluation. FDG-PET can be regarded as accepted imaging modality in the restaging of seminomatous germ cell tumors after chemotherapy.
使用（（18）F）2-氟-D：-2-脱氧葡萄糖（FDG）的正电子发射断层扫描（PET）已被研究作为一种高度敏感和特异的成像方式，用于诊断原发性和复发性肿瘤以及控制多种非泌尿生殖系统癌症的治疗。本综述的目的是验证PET作为诊断工具在小骨盆恶性泌尿生殖系统肿瘤中的意义。对当前有关PET在恶性前列腺、睾丸和膀胱肿瘤中作用的文献进行了系统综述。数据表明，与传统成像相比，PET在前列腺癌、膀胱癌或睾丸癌的肿瘤检测和局部分期中没有额外作用。前列腺癌中的肿瘤复发似乎用醋酸盐和胆碱比用FDG能更有效地识别，但在前列腺特异性抗原（PSA）值较高时这种效果更明显。由于部分临床数据缺失、存在争议或正在评估中，PET在识别任何一种肿瘤实体中的转移疾病方面的价值最终无法确定。FDG-PET可被视为化疗后精原性生殖细胞肿瘤再分期中被认可的成像方式。
