声带息肉中基质金属蛋白酶（MMP - 2和MMP - 9）及环氧化酶 - 2（COX - 2）的表达

Matrix Metalloproteinases (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) expressions in vocal fold polyps.

作者信息

Karahan Nermin, Baspinar Sirin, Yariktas Murat, Kapucuoglu Nilgun

机构信息

Department of Pathology, Suleyman Demirel University School of Medicine, Isparta, Turkey.

出版信息

J Voice. 2009 Jan;23(1):29-33. doi: 10.1016/j.jvoice.2007.05.005. Epub 2007 Jul 12.

DOI:10.1016/j.jvoice.2007.05.005

PMID:17624726

Abstract

The objective of this study was to investigate the roles of matrix metalloproteinases (MMP-2, MMP-9) and cyclooxygenase-2 (COX-2) in the pathogenesis of vocal fold polyps (VFPs). In this study, 20 VFPs and 8 normal vocal fold (VF) specimens were obtained from subjects undergoing surgery. Staining intensities were semiquantitatively assessed and statistically analyzed. Significant increases were observed in the expressions of MMP-2, MMP-9, and COX-2 in stromal spindle cells (P=0.00) and vascular wall (P=0.04, P=0.00, P=0.00) of VFPs compared with normal VFs. MMP-2 expression in surface epithelium basal cells (P=0.00) of VFPs showed enhancement compared with normal vocal folds, whereas MMP-9 and COX-2 expressions showed no significant differences. Our study showed that gelatinases and COX-2 may play a role in the development of VFPs. This is the first study to document the expression of gelatinases and COX-2 in VFPs.

摘要

本研究的目的是探讨基质金属蛋白酶（MMP - 2、MMP - 9）和环氧化酶 - 2（COX - 2）在声带息肉（VFP）发病机制中的作用。在本研究中，从接受手术的受试者身上获取了20个声带息肉标本和8个正常声带（VF）标本。对染色强度进行半定量评估并进行统计学分析。与正常声带相比，声带息肉的基质梭形细胞（P = 0.00）和血管壁（P = 0.04、P = 0.00、P = 0.00）中MMP - 2、MMP - 9和COX - 2的表达显著增加。声带息肉表面上皮基底细胞中的MMP - 2表达（P = 0.00）与正常声带相比有所增强，而MMP - 9和COX - 2的表达无显著差异。我们的研究表明，明胶酶和COX - 2可能在声带息肉的发生发展中起作用。这是首次记录明胶酶和COX - 2在声带息肉中表达的研究。