Gepner Adam D, Wyman Rachael A, Korcarz Claudia E, Aeschlimann Susan E, Stein James H
University of Wisconsin Atherosclerosis Imaging Research Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA.
J Am Soc Echocardiogr. 2007 Nov;20(11):1269-75. doi: 10.1016/j.echo.2007.03.009. Epub 2007 Jul 10.
Carotid intima-media thickness (CIMT) testing can assist with cardiovascular risk prediction; however, the requirement for rigorous, time-consuming protocols has limited it use in clinical practice.
Bilateral images of the common carotid artery (CCA), bulb, and internal carotid artery segments were obtained using a comprehensive scanning protocol. Three abbreviated scanning protocols were evaluated for their ability to identify patients with increased CIMT (> or = 75th percentile).
Of 261 subjects, 134 (51.3%) had increased left or right CCA CIMT (CCA protocol), 136 (52.1%) had carotid plaque (plaque protocol), and 190 (72.7%) had plaque or at least one increased CCA CIMT (combination protocol). The area under the receiver-operator characteristic curves for the CCA (0.738) and combination protocols (0.692) were higher than the plaque protocol (0.625, P < .05). The combination protocol was 100% sensitive.
Compared with a comprehensive scanning protocol, plaque screening with measurement of far wall CCA CIMT identifies all patients with increased CIMT.
颈动脉内膜中层厚度（CIMT）检测有助于心血管风险预测；然而，因其需要严格、耗时的检测流程，限制了其在临床实践中的应用。
采用全面扫描方案获取双侧颈总动脉（CCA）、颈动脉球部及颈内动脉节段的图像。对三种简化扫描方案识别CIMT增加（≥第75百分位数）患者的能力进行评估。
在261名受试者中，134名（51.3%）左侧或右侧CCA的CIMT增加（CCA方案），136名（52.1%）有颈动脉斑块（斑块方案），190名（72.7%）有斑块或至少一侧CCA的CIMT增加（联合方案）。CCA方案（0.738）和联合方案（0.692）的受试者操作特征曲线下面积高于斑块方案（0.625，P<0.05）。联合方案的敏感性为100%。
与全面扫描方案相比，通过测量CCA远壁CIMT进行斑块筛查可识别所有CIMT增加的患者。
