阿魏酸酯二聚体的合成、功能化及作为潜在抗动脉粥样硬化和抗疟原虫药物的生物学评价。
Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents.
作者信息
Rakotondramanana D L A, Delomenède Mélanie, Baltas Michel, Duran Hubert, Bedos-Belval Florence, Rasoanaivo Philippe, Negre-Salvayre Anne, Gornitzka Heinz
机构信息
Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique, LSPCMIB, UMR-CNRS 5068, Université Paul Sabatier, 118, Route de Narbonne, 31062 Toulouse Cedex 9, France.
出版信息
Bioorg Med Chem. 2007 Sep 15;15(18):6018-26. doi: 10.1016/j.bmc.2007.06.047. Epub 2007 Jun 29.
Oxidative dimerization of ferulic acid methyl ester afforded dihydrobenzofuran derivative and new linear compound identified by X-ray crystallography. The gallate derivatized dihydrobenzofuran analogue was obtained and all compounds were evaluated for potential antiatherogenic, antiplasmodial (best IC(50)=0.8 microM) and cytotoxic activities.
阿魏酸甲酯的氧化二聚反应得到了二氢苯并呋喃衍生物和通过X射线晶体学鉴定的新型线性化合物。制备了没食子酸衍生的二氢苯并呋喃类似物，并对所有化合物的潜在抗动脉粥样硬化、抗疟原虫（最佳IC50 = 0.8 microM）和细胞毒性活性进行了评估。
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