Saint D A, Buckett K J
Division of Neuroscience, John Curtin School of Medical Research, Canberra ACT, Austrlia.
Neuropeptides. 1991 Nov;20(3):151-7. doi: 10.1016/0143-4179(91)90124-2.
Cholecystokinin (CCK) affects neuronal excitability in a variety of in vivo and in vitro preparations, apparently by modulating a resting potassium conductance. The data presented here show that CCK (applied as CCK8-S) also affects the transient potassium current in hippocampal neurones, by changing the voltage dependence of the inactivation and activation of the current. The way in which the voltage dependence is changed can lead to either an enhancement of the current or an attenuation, depending upon the voltage protocol used. This effect of CCK does not desensitise over a time period of minutes, and may therefore be important in controlling neuronal excitability in the CNS.
胆囊收缩素（CCK）在多种体内和体外实验制剂中影响神经元兴奋性，显然是通过调节静息钾电导来实现的。此处呈现的数据表明，CCK（以CCK8-S形式应用）还通过改变海马神经元瞬时钾电流失活和激活的电压依赖性来影响该电流。电压依赖性改变的方式会导致电流增强或减弱，这取决于所使用的电压方案。CCK的这种作用在数分钟的时间段内不会脱敏，因此可能在控制中枢神经系统的神经元兴奋性方面具有重要意义。
