恶性疟原虫疟疾疫苗候选var基因中DBLα结构域的B细胞和T细胞表位预测
Prediction of B cell and T cell epitopes of DBLalpha domain in Plasmodium falciparum malaria vaccine candidate var gene.
作者信息
Ozarkar Aarti D, Prakash D, Deobagkar Dileep N, Deobagkar Deepti D
机构信息
Molecular Biology Research Laboratory, Department of Zoology and Institute of Bioinformatics and Biotechnology, University of Pune, Pune-411007, India.
出版信息
Protein Pept Lett. 2007;14(6):528-30. doi: 10.2174/092986607780989967.
PMID:17627591
Abstract
P. falciparum encodes PfEMP-1 which is important in pathogenicity and virulence. We have analyzed the structure of the Duffy binding like (DBLalpha) domain of var genes and predicted the antigenic sites and T and B cell epitopes which present a highly variable picture with major implications in immune interactions and vaccine design.
摘要
恶性疟原虫编码的恶性疟原虫红细胞膜蛋白1（PfEMP-1）在致病性和毒力方面很重要。我们分析了var基因的达菲结合样（DBLα）结构域的结构，并预测了抗原位点以及T细胞和B细胞表位，这些呈现出高度可变的情况，对免疫相互作用和疫苗设计具有重要意义。
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