Turner S M, Faisal M, DeWoody J A
Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN, USA.
Anim Genet. 2007 Oct;38(5):517-9. doi: 10.1111/j.1365-2052.2007.01631.x. Epub 2007 Jul 13.
Major histocompatibility (MH) class II genes play an important role in the vertebrate immune response. Here, we investigate the relationship between Atlantic salmon (Salmo salar) MH class IIB zygosity and susceptibility to Renibacterium salmoninarum, the causal agent of bacterial kidney disease. By combining DNA sequences from the salmon MH class IIB gene with quantitative ELISA data on R. salmoninarum antigen levels, we found that MH class IIB homozygotes were significantly more susceptible to R. salmoninarum than heterozygotes. These findings are discussed in the context of current evolutionary theory.
主要组织相容性（MH）II类基因在脊椎动物免疫反应中起重要作用。在此，我们研究了大西洋鲑（Salmo salar）MH IIB类基因的纯合性与对鲑肾杆菌（细菌性肾病的病原体）易感性之间的关系。通过将鲑MH IIB类基因的DNA序列与关于鲑肾杆菌抗原水平的定量ELISA数据相结合，我们发现MH IIB类纯合子比杂合子对鲑肾杆菌更易感。我们在当前进化理论的背景下讨论了这些发现。
