植物病原细菌中的全球毒力调控网络。

Global virulence regulation networks in phytopathogenic bacteria.

作者信息

Mole Beth M, Baltrus David A, Dangl Jeffery L, Grant Sarah R

机构信息

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

出版信息

Trends Microbiol. 2007 Aug;15(8):363-71. doi: 10.1016/j.tim.2007.06.005. Epub 2007 Jul 12.

DOI:10.1016/j.tim.2007.06.005

PMID:17627825

Abstract

Phytopathogens coordinate multifaceted life histories and deploy stratified virulence determinants via complex, global regulation networks. We dissect the global regulation of four distantly related model phytopathogens to evaluate large-scale events and mechanisms that determine successful pathogenesis. Overarching themes include dependence on centralized cell-to-cell communication systems, pervasive two-component signal-transduction systems, post-transcriptional regulation systems, AraC-like regulators and sigma factors. Although these common regulatory systems control virulence, each functions in different capacities, and to differing ends, in the diverse species. Hence, the virulence regulation network of each species determines its survival and success in various life histories and niches.

摘要

植物病原体通过复杂的全局调控网络协调多方面的生活史，并部署分层的毒力决定因素。我们剖析了四种亲缘关系较远的模式植物病原体的全局调控，以评估决定成功致病的大规模事件和机制。总体主题包括对集中式细胞间通讯系统、普遍存在的双组分信号转导系统、转录后调控系统、AraC样调节因子和σ因子的依赖。尽管这些共同的调控系统控制着毒力，但它们在不同物种中以不同的能力和不同的目的发挥作用。因此，每个物种的毒力调控网络决定了其在各种生活史和生态位中的生存与成功。